Pharmacy World and Science

, Volume 19, Issue 3, pp 126–132

Etoposide phosphate, the water soluble prodrug of etoposide

Authors

  • R.C. Bakker
    • Department of Internal Medicine,Onze Lieve Vrouwe Gasthuis,
    • Department of Internal Medicine,Slotervaart Hospital, Louwesweg 6,
  • D.P.M. Brandjes
    • Department of Internal Medicine,Onze Lieve Vrouwe Gasthuis,
Article

DOI: 10.1023/A:1008634632501

Cite this article as:
Bakker, R. & Brandjes, D. Pharm World Sci (1997) 19: 126. doi:10.1023/A:1008634632501

Abstract

An elevated plasma homocysteine level may result from various enviromental and genetic factors. Hereditary causes of severe hyperhomo-cysteinaemia are very rare and usually lead to disease in childhood or adolescence. Common pathology consists of early atherosclerotic vascular changes, arterioocclusive complications and venous thrombosis. Mildly elevated genetically determined plasma homocysteine levels are observed in 5% of the general population. In the last two decades research has shown mild hyperhomocysteinaemia to be linked to an increased risk of premature atherosclerosis, pregnancies complicated by neural tube defects and early pregnancy loss, and venous thrombosis. Homozygosity for thermolabile MTHFR deficiency has been identified as one important genetic factor, which expression is modified by dietary folate intake. Although mild hyperhomocysteinaemia can easily be treated by vitamin supplementation the beneficial effects of such treatment remains to be shown.

Homcysteine Hyperhomocysteinaemia

Copyright information

© Kluwer Academic Publishers 1997