Cardiovascular Drugs and Therapy

, Volume 11, Issue 3, pp 485–491

Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil and Mustard Oil in Patients with Suspected Acute Myocardial Infarction: The Indian Experiment of Infarct Survival—4

  • Ram B. Singh
  • Mohammad A. Niaz
  • Jagdish P. Sharma
  • Rakesh Kumar
  • Vipul Rastogi
  • M. Moshiri
Article

DOI: 10.1023/A:1007757724505

Cite this article as:
Singh, R.B., Niaz, M.A., Sharma, J.P. et al. Cardiovasc Drugs Ther (1997) 11: 485. doi:10.1023/A:1007757724505

Abstract

In a randomized, placebo-controlled trial, the effects of treatment with fish oil (eicosapentaenoic acid, 1.08 g/day) and mustard oil (alpha-linolenic acid, 2.9 g/day) were compared for 1 year in the management of 122 patients (fish oil, group A), 120 patients (mustard oil, group B), and 118 patients (placebo, group C) with suspected acute myocardial infarction (AMI). Treatments were administered about (mean) 18 hours after the symptoms of AMI in all three groups. The extent of cardiac disease, rise in cardiac enzymes, and lipid peroxides were comparable among the groups at entry into the study. After 1 year total cardiac events were significantly less in the fish oil and mustard oil groups compared with the placebo group (24.5% and 28% vs. 34.7%, p > 0.01). Nonfatal infarctions were also significantly less in the fish oil and mustard oil groups compared with the placebo group (13.0% and 15.0% vs. 25.4%, p > 0.05). Total cardiac deaths showed no significant reduction in the mustard oil group; however, the fish oil group had significantly less cardiac deaths compared with the placebo group (11.4% vs. 22.0%, p > 0.05). Apart from the decrease in the cardiac event rate, the fish oil and mustard oil groups also showed a significant reduction in total cardiac arrhythmias, left ventricular enlargement, and angina pectoris compared with the placebo group. Reductions in blood lipoproteins in the two intervention groups were modest and do not appear to be the cause of the benefit in the two groups. Diene conjugates showed a significant reduction in the fish oil and mustard oil groups, indicating that a part of the benefit may be caused by the reduction in oxidative stress. The findings of this study suggest that fish oil and mustard oil, possibly due to the presence of n-3 fatty acids, may provide rapid protective effects in patients with AMI. However, a large study is necessary to confirm this suggestion.

alpha linolenic acid eicosapentaenoic acid fish oil mustard oil acute myocardial infarction 

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Ram B. Singh
    • 1
    • 2
  • Mohammad A. Niaz
    • 1
    • 2
  • Jagdish P. Sharma
    • 1
    • 2
  • Rakesh Kumar
    • 1
    • 2
  • Vipul Rastogi
    • 1
    • 2
  • M. Moshiri
    • 1
    • 2
  1. 1.Heart Research LaboratoryMedical Hospital and Research Centre, Civil LinesMoradabadIndia
  2. 2.Rajaie Cardiovascular Medical CentreTehranIran