Cardiovascular Drugs and Therapy

, Volume 12, Issue 5, pp 463–467

Moxonidine Effect on Microalbuminuria, Thrombomodulin, and Plasminogen Activator Inhibitor-1 Levels in Patients with Essential Hypertension

  • Panagiota G. Krespi
  • Thomas K. Makris
  • Antonios N. Hatzizacharias
  • Philippos Triposkiadis
  • Catherine Tsoukala
  • Despina Kyriaki
  • Vassilios Votteas
  • Michael Kyriakidis
Article

DOI: 10.1023/A:1007702132210

Cite this article as:
Krespi, P.G., Makris, T.K., Hatzizacharias, A.N. et al. Cardiovasc Drugs Ther (1998) 12: 463. doi:10.1023/A:1007702132210

Abstract

Increased sympathetic activity seems to play an important role in the pathogenesis and development of complications of atherosclerotic origin in patients with essential hypertension (EH). The aim of this study was to evaluate the effect of a new antihypertensive agent, moxonidine (M), on microalbuminuria (urine albumin excretion, UAE), plasma thrombomodulin (TM), and tissue plasminogen activator inhibitor (PAI-1) in patients with mild to moderate EH associated with increased UAE. Fifty-eight patients (32 M, 26 F) with EH and microalbuminuria, with a mean age of 56.6 ± 8.2 years and a body mass index (BMI) of 23.8 ± 3.1 kg/m2 who responded to M therapy (0.3–0.4 mg/daily) were studied before and after their blood pressure control. The 24-hour urine albumin excretion (RIA method), as well as TM and PAI-1 plasma levels (ELISA method), were determined before and 6 months after the initiation of treatment under moxonidine therapy. At the end of the 6-month period, all patients remained normotensive. The 24-hour urine albumin excretion had decreased to 24.5 ± 6.4 vs. 32.3 ± 7.2 ug/min before therapy (P < 0.001). The plasma TM levels had decreased to 44.0 ± 7 vs. 51.0 ± 9 ng/mL before therapy (P < 0.01), and PAI-1 levels had also decreased to 11.5 ± 4.5 vs. 15.8 ± 8 IU/mL before therapy (P < 0.05). The results of our study suggest that in hypertensive patients with microalbuminuria, moxonidine, an imidazoline I1-receptor agonist, a new centrally acting antihypertensive agent, significantly reduces urine albumin excretion as well as thrombomodulin and PAI-1 levels. These preliminary findings demonstrate a favorable effect on renal function and endothelial homeostatic mechanisms (maintenance of haemostatic balance).

moxonidinemicroalbuminuriathrombomodulinplasminogen activator inhibitor-1essential hypertension

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Panagiota G. Krespi
    • 1
    • 2
  • Thomas K. Makris
    • 1
  • Antonios N. Hatzizacharias
    • 1
  • Philippos Triposkiadis
    • 1
  • Catherine Tsoukala
    • 1
  • Despina Kyriaki
    • 1
  • Vassilios Votteas
    • 1
  • Michael Kyriakidis
    • 1
  1. 1.Department, of Cardiology, 2nd Reg. BTCAthens University, Medical SchoolGreece
  2. 2.Haemostasis Lab, Department of Nuclear Medicine“LAIKON” General HospitalAthensGreece