European Journal of Epidemiology

, Volume 14, Issue 8, pp 791–796

Congenital cytomegalovirus infection in a northern Italian region

  • M. Barbi
  • S. Binda
  • V. Primache
  • D. Clerici
Article

DOI: 10.1023/A:1007554726449

Cite this article as:
Barbi, M., Binda, S., Primache, V. et al. Eur J Epidemiol (1998) 14: 791. doi:10.1023/A:1007554726449

Abstract

Knowledge of the prevalence of congenital cytomegalovirus infection is necessary to evaluate the need for prevention. We performed a multicentre one-year study involving 11 neonatology divisions to ascertain the prevalence in Lombardy. Cytomegalovirus was isolated by culturing saliva samples from all babies born (n=1268) of two 15-day sample periods and from 185 neonates with suspected congenital CMV based on clinical and laboratory findings and the history. The overall prevalence of congenital infection was 0.47% (6/1268) in the sample period group and 5% (9/185) in the second group. Clinical monitoring revealed sequelae in two of three children with symptomatic infection and no asymptomatic child at age two years. In a subgroup of 205 babies including 14 of the infected infants we also evaluated a test to detect cytomegalovirus DNA in the Guthrie cards obtained in neonatal screening for genetic and metabolic disorders. The test's sensitivity was 100% and specificity 98.5%, encouraging its use for early identification of infected neonates and for large epidemiological studies.

Congenital infectionCytomegalovirusGuthrie cardPolymerase chain reaction (PCR)

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • M. Barbi
    • 1
  • S. Binda
    • 1
  • V. Primache
    • 1
  • D. Clerici
    • 2
  1. 1.Institute of VirologyUniversity of MilanItaly
  2. 2.Neonatology division, Institute of PediatricsUniversity of MilanMilanItaly