R. J. Mumper, J. J. Wang, S. L. Klakamp, H. Nitta, K. Anwer, F. Tagliaferri, and A. P. Rolland. Protective interactive noncon-densing (PINC) polymers for enhanced plasmid distribution and expression in rat skeletal muscle. J. Contr. Rel.
A. Maruyama, T. Ishihara, J. S. Kim, S. W. Kim, and T. Akaike. Nanoparticle DNAcarrier with poly(L-lysine) grafted polysaccharide copolymer and poly(D,L-lactic acid). Bioconjug. Chem.
P. L. Felgner, Y. Barenholz, J. P. Behr, S. H. Cheng, P. Cullis, L. Huang, J. A. Jessee, L. Seymour, F. Szoka, A. R. Thierry, E. Wagner, and G. Wu. Nomenclature for synthetic gene delivery systems. Hum. Gene Ther.
J. E. Duncan, J. A. Whitsett, and A. D. Horowitz. Pulmonary surfactant inhibits cationic liposome-mediated gene delivery to respiratory epithelial cells in vitro. Hum. Gene Ther.
N. Ernst, S. Ulrichskötter, W. A. Schmalix, J. Rädler, R. Galneder, E. Mayer, S. Gersting, C. Plank, D. Reinhardt, and J. Rosenacker. Interaction of liposomal and polycationic transfection complexes with pulmonray surfactant. J. Gen. Med. Preprint
1: in press (1999).
P. L. Felgner. Non viral strategies for gene therapy. Sci. Am.
E. Tomlinson and A. P. Rolland. Controllable gene therapy- pharmaceutics of non-viral gene delivery systems. J. Contr. Rel.
F. D. Ledley. Pharmaceutical approach to somatic gene therapy. Pharm. Res.
J. S. Remy, B. Abdallah, M. A. Zanta, O. Boussif, J. P. Behr, and B. Demeneix. Gene transfer with lipospermines and polyethylene-imines. Adv. Drug Deliv. Rev.
W. Zauner, M. Ogris, and E. Wagner. Polylysine-based transfection systems utilizing receptor-mediated delivery. Adv. Drug Del. Rev.
T. Takai and H. Ohmori. DNA transfection of mouse lymphoid-cells by the combination of DEAE-dextran-mediated DNA uptake and osmotic shock procedure. Biochim. Biophys. Acta
G. Y. Wu and C. H. Wu. Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. J. Biol. Chem. 4429-4432 (1987).
L. C. Smith, J. Duguid, M. S. Wadhwa, M. J. Logan, C. H. Tung, V. Edwards, and J. T. Sparrow. Synthetic peptide-based DNA complexes for nonviral gene delivery. Adv. Drug Del. Rev.
J. G. Duguid, C. Li, M. Shi, M. J. Logan, H. Alila, A. Rolland, E. Tomlinson, J. T. Sparrow, and L. C. Smith. A physicochemical approach for predicting the effectiveness of peptide-based gene delivery systems for use in plasmid-based gene therapy. Biophys. J.
A. V. Kabanov and V. A. Kabanov. Interpolyelectrolyte and block ionomer complexes for gene delivery: physicochemical aspects. Adv. Drug Del. Rev.
M. A. Wolfert, E. H. Schacht, V. Toncheva, K. Ulbrich, O. Nazarova, and L. W. Seymour. Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers. Hum. Gene Ther.
V. Toncheva, M. A. Wolfert, P. R. Dash, D. Oupicky, K. Ulbrich, L. W. Seymour, and E. H. Schacht. Novel Vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers. Biochim. Biophys. Acta Gen. Rev.
A. Maruyama, M. Katoh, T. Ishihara, and T. Akaike. Comb-type polycations effectively stabilize DNA triplex. Bioconjug. Chem.
A. Maruyama, H. Watanabe, A. Ferdous, M. Katoh, T. Ishihara, and T. Akaike. Characterization of interpolyelectrolyte complexes between double-stranded DNA and polylysine comb-type copolymers having hydrophilic side chains. Bioconjug. Chem.
S. Katayose and K. Kataoka. Water-soluble polyion complex associates of DNA and poly(ethylene glycol) poly(L-lysine) block copolymer. Bioconjug. Chem.
S. Katayose and K. Kataoka. Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol) poly(L-lysine) block copolymer. J. Pharm. Sci.
J. Haensler and F. C. J. Szoka. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug. Chem. 372-379 (1993).
O. Boussif, M. A. Zanta, and J. P. Behr. Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold. Gene Ther.
M. A. Zanta, O. Boussif, A. Adib, and J. P. Behr. In vitro gene delivery to hepatocytes with galactosylated polyethylenimine. Bioconjug. Chem.
O. Boussif, F. Lezoualc'h, M. A. Zanta, M. D. Mergny, D. Scherman, B. Demeneix, and J. P. Behr. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. USA
S. Ferrari, E. Moro, A. Pettenazzo, J. P. Behr, F. Zacchello, and M. Scarpa. ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo. Gene Ther.
J.-Y. Cherng, P. van de Wetering, H. Talsma, D. J. A. Crommelin, and W. E. Hennink. Effect of size and serum proteins on transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles. Pharm. Res.
P. van de Wetering, J.-Y. Cherng, H. Talsma, and W. E. Hennink. Relation between transfection efficiency and cytotoxicity of poly(2-(dimethylamino)ethyl mathacrylate)/plasmid complexes. J. Cont. Rel.
F. C. MacLaughlin, R. J. Mumper, J. Wang, F. Tagliaferri, I. Gill, M. Hinchcliffe, and A. Rolland. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J. Contr. Rel.
G. Y. Wu and C. H. Wu. Evidence for targeted gene delivery to Hep G2 hepatoma cells in vitro. Biochemistry
A. V. Kabanov and V. A. Kabanov. DNA complexes with polycations for the delivery of genetic material into cells. Bioconjug.
A. Kichler, W. Zauner, C. Morrison, and E. Wagner. Ligand-polylysine mediated gene transfer. In P. L. Felgner, M. J. Heller, P. Lehn, J.-P. Behr, and F. C. Szoka, Jr. (eds.), Artificial Self-Systems for Gene Delivery, ACS, Washington, pp 120-128, 1996.
V. A. Bloomfield. Condensation of DNA by multivalent cations: considerations on mechanism. Biopolymers
V. A. Bloomfield. DNA condensation. Curr. Opin. Struc. Biol.
C. W. Pouton, P. Lucas, B. J. Thomas, A. N. Uduehi, D. A. Milroy, and S. H. Moss. Polycation-DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids. J. Contr. Rel.
S. Y. Park, D. Harries, and W. M. Gelbart. Topological defects and the optimum size of DNA condensates. Biophys. J.
M. X. Tang and F. C. Szoka. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Therapy
M. A. Wolfert and L. W. Seymour. Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA. Gene Ther.
A. U. Bielinska, J. F. KukowskaLatallo, and J. R. Baker. The interaction of plasmid DNA with polyamidoamine dendrimers: mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed DNA. Biochim. Biophys. Acta
J. Pelta, F. Livolant, and J. L. Sikorav. DNA aggregation induced by polyamines and cobalthexamine. J. Biol. Chem.
J. S. Kim, A. Maruyama, T. Akaike, and S. W. Kim. Terplex DNA delivery system as a gene carrier. Pharm. Res.
J.-Y. Cherng, N. M. E. Schuurmans-Nieuwenbroek, W. Jiskoot, H. Talsma, N. J. Zuidam, W. E. Hennink, and D. J. A. Crommelin. Effect of DNA topology on the transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid complexes. J. Contr. Rel. (1999, in press).
E. Wagner, M. Cotten, R. Foisner, and M. L. Birnstiel. Transferrin-4: polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. Proc. Natl. Acad. Sci. USA
R. C. Adami, W. T. Collard, S. A. Gupta, K. Y. Kwok, J. Bonadio, and K. G. Rice. Stability of peptide condensed plasmid DNA formulations. J. Pharm. Sci.
R. J. Mumper, J. Wang, J. M. Claspell, and A. P. Rolland, A. P. (1995) Novel polymeric condensing carriers for gene delivery. Proc. Intern. Symp. Control. Rel. Bioact. Mater.
P. G. Arscott and V. A. Bloomfield. Condensation of DNA by trivalent cations. 1. Effects of DNA length and topology on the size and shape of condensed particles. Biopolymers
J. S. Kim, A. Maruyama, T. Akaike, and S. W. Kim. In vitro gene expression on smooth muscle cells using a terplex delivery system. J. Contr. Rel.
J. C. Perales, G. A. Grossmann, M. Molas, G. Liu, T. Ferkol, J. Harpst, H. Oda, and R. W. Hanson. Biochemical and functional characterization of DNA complexes capable of targeting genes to hepatocytes via the asialoglycoprotein receptor. J Biol. Chem.
C. Plank, K. Mechtler, F. C. Szoka, and E. Wagner. Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery. Hum. Gene Ther.
P. Erbacher, M. T. Bousser, J. Raimond, M. Monsigny, P. Midoux, and A. C. Roche. Gene transfer by DNA/glycosylated polylysine complexes into human blood monocyte-derived macrophages. Hum. Gene Ther.
P. Erbacher, A. C. Roche, M. Monsigny, and P. Midoux. The reduction of the positive charges of polylysine by partial gluconoylation increases the transfection efficiency of polylysine/DNA complexes. Biochim. Biophys. Acta Biomembr.
L. Bromberg and G. Levin. Conjugates of polylysine and oligo(N,N-diethylacrylamide) as temperature-sensitive agents in DNA condensation. Macromol. Rapid Comm.
S. Asayama, A. Maruyama, C. S. Cho, and T. Akaike. Design of comb-type polyamine copolymers for a novel pH-sensitive DNA carrier. Bioconjug. Chem.
P. van de Wetering, N. J. Zuidam, M. J. van Steenbergen, O. A. G. J. van der Houwen, W. J. M. Underberg, and W. E. Hennink. Amechanistic study of the hydrolytic stability of poly(2-(dimethy-lamino)ethyl methacrylate). Macromolecules
I. R. Miller and D. Bach. Interaction of DNA with heavy metal ions and polybases. Biopolymers
M. Ruponen, S. Yla-Herttuala, and A. Urtti. Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies. Biochem. Biophys. Acta
V. A. Izumrudov, M. V. Zhiryakova, S. I. Kargov, A. B. Zezin, and V. A. Kabanov. Competitive reactions in solutions of DNA-containing polyelectrolyte complexes. Macromol. Symp.
P. R. Dash, V. Toncheva, E. Schacht, and L. W. Seymour. Synthetic polymers for vectorial delivery of DNA: characterisation of polymer-DNA complexes by photon correlation spectroscopy and stability to nuclease degradation and disruption by polyanions in vitro. J. Contr. Rel.
T. Wink, J. de Beer, P. J. H. J. van Oss, W. N. E. van Dijk-Wolthuis, N. J. Zuidam, W. E. Hennink, A. Bult, and W. P. van Bennekom. Interaction between plasmid DNA and cationic polymers studied with surface plasmon resonance spectrometry. Anal. Chem.
J. P. Yang and L. Huang. Direct gene transfer to mouse melanoma by intratumor injection of free DNA. Gene Ther.
M. Ogris, P. Steinlein, M. Kursa, K. Mechtler, R. Kircheis, and E. Wagner. The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther.
M. R. Capecchi. High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell
B. Meyer, L. S. Uyechi, and F. C. J. Szoka. Manipulating the trafficking of nucleic acids. In K. L. Brigham (ed.), Gene Therapy for Diseases of the Lung, Marcel Dekker, New York, 1997, pp 135-180.
M. Wilke, E. Fortunati, M. van den broek, A. T. Hoogeveen, and B. J. Scholte. Efficacy of a peptide-based gene delivery system depends on mitotic activity. Gene Ther.
K. Luby Phelps, P. E. Castle, D. L. Taylor, and F. Lanni. Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells. Proc. Natl. Acad. Sci. USA
E. A. Nigg. Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature
M. X. Tang, C. T. Redemann, and F. C. Szoka. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug. Chem.
J. P. Behr. L' éponge àprotons: un moyen d'entrer dans une cellule auquel les virus n'ont pas pense´. Me´dicine/Sciences
K. A. Mislick and J. D. Baldeschwieler. Evidence for the role of proteoglycans in cation-mediated gene transfer. Proc. Natl. Acad. Sci. USA
A. A. Yaroslavov, S. A. Sukhishvili, O. L. Obolsky, E. G. Yaroslavova, A. V. Kabanov, and V. A. Kabanov. DNA affinity to biological membranes is enhanced due to complexation with hydrophobized polycation. FEBS lett.
P. van de Wetering, J.-Y. Cherng, H. Talsma, D. J. A. Crommelin, and W. E. Hennink. 2-(Dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents. J. Contr. Rel.
Y. H. Choi, F. Liu, J. S. Kim, Y. K. Choi, J. S. Park, and S. W. Kim. Polyethylene glycol-grafted poly-L-lysine as polymeric gene carrier. J. Contr. Rel.
M. Yamazaki and T. Ito. Deformation and instability in membrane structure of phospholipid vesicles caused by osmophobic association: mechanical stress model for the mechanism of poly(ethylene glycol)-induced membrane fusion. Biochemistry
N. Nelson. Structure and morphology of the proton-ATPases. Trends Pharmacol. Sci.
P. O. Seglen. Inhibitors of lysosomal function. Methods Enzymol.
P. Erbacher, A. C. Roche, M. Monsigny, and P. Midoux. Putative role of chloroquine in gene transfer into a human hepatoma cell line by DNA lactosylated polylysine complexes. Exp. Cell Res.
D. T. Curiel, S. Agarwal, E. Wagner, and M. Cotten. Adenovirus enhancement of transferrin polylysine-mediated gene delivery. Proc. Natl. Acad. Sci. USA
M. Cotten, E. Wagner, K. Zatloukal, S. Phillips, D. T. Curiel, and M. L. Birnstiel. High-efficiency receptor-mediated delivery of small and large (48 kilobase) gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. Proc. Natl. Acad. Sci. USA
E. Wagner, K. Zatloukal, M. Cotten, H. Kirlappos, K. Mechtler, D. T. Curiel, and M. L. Birnstiel. Coupling of adenovirus to transferrin polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proc. Natl. Acad. Sci. USA
J. D. Lear and W. F. DeGrado. Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA2. J. Biol. Chem.
C. Plank, B. Oberhauser, K. Mechtler, C. Koch, and E. Wagner. The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J. Biol. Chem.
W. Zauner, D. Blaas, E. Kuechler, and E. Wagner. Rhinovirus-mediated endosomal release of transfection complexes. J. Virol.
A. F. Santos, N. Murthy, P. S. Stayton, O. W. Press, D. A. Tirell, and A. S. Hoffman. Design of polymers to increase the efficiency of endosomal release of drugs. J. Invest. Med.
J. L. Thomas, B. P. Devlin, and D. A. Tirrell. Kinetics of membrane micellization by the hydrophobic polyelectrolyte poly(2-ethyla-intracellular crylic acid). Biochim. Biophys. Acta Biomembr.
E. G. Marcusson, B. Bhat, M. Manoharan, C. F. Bennett, and N. M. Dean. Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus. Nucleic Acids Res.
G. Stingl, E. B. Brocker, R. Mertelsmann, K. Wolff, S. Schreiber, E. Kampgen, A. Schneeberger, W. Dummer, U. Brennscheid, H. Veelken, M. L. Birnstiel, K. Zatloukal, W. Schmidt, G. Maass, E. Wagner, M. Buschle, M. Giese, E. R. Kempe, H. A. Weber H A, and T. Voigt. Phase I study to the immunotherapy of metastatic malignant melanoma by a cancer vaccine consisting of autologous cancer cells transfected with the human IL-2 gene. Hum. Gene Ther.
R. Kircheis, S. Schüller, S. Brunner, M. Ogris, K.-H. Heider, W. Zauner, and E. Wagner. Polycation-based DNA complexes for tumor-targeted gene delivery in vivo. J. Gen. Med. Preprint d11-16 (1999).
G. Y. Wu and C. H. Wu. Receptor-mediated gene delivery and expression in vivo. J. Biol. Chem.
N. R. Chowdhury, C. H. Wu, G. Y. Wu, V. R. Yerneni, V. R. Bommineni, and J. R. Chowdhury. Fate of DNA targeted to the liver by asialoglycoprotein receptor-mediated endocytosis in vivo. J. Biol. Chem. 68:2341-2346 (1993).
J. C. Perales, T. Ferkol, H. Beegen, O. D. Ratnoff, and R. W. Hanson. Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake. Proc. Natl. Acad. Sci. USA
M. Hashida, S. Takemura, M. Nishikawa, and Y. Takakura. Targeted delivery of plasmid DNA complexed with galactosylated poly(L-Lysine). J. Contr. Rel.
T. Ferkol, J. C. Perales, E. Eckman, C. S. Kaetzel, R. W. Hanson, and P. B. Davis. Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor. J. Clin. Invest.
B. Schwartz, C. Benoist, B. Abdallah, R. Rangara, A. Hassan, D. Scherman, and B. A. Demeneix. Gene transfer by naked DNA into adult mouse brain. Gene Ther.
A. Boletta, A. Benigni, J. Lutz, G. Remuzzi, M. R. Soria, and L. Monaco. Nonviral gene delivery to the rat kidney with polyethy-lenimine. Hum. Gene Ther.
L. H. Qin, D. R. Pahud, Y. Z. Ding, A. U. Bielinska, J. F. KukowskaLatallo, J. R. Baker, and J. S. Bromberg. Efficient transfer of genes into murine cardiac grafts by starburst polyamidoamine dendrimers. Hum. Gene Ther.
S. Asayama, M. Nogawa, Y. Takei, T. Akaike, and A. Maruyama. Synthesis of novel polyampholyte comb-type copolymers consisting of a poly(L-lysine) backbone and hyaluronic acid side chains for a DNA carrier. Bioconjug. Chem.
C. H. Wu, J. M. Wilson, and G. Y. Wu. Targeting genes: delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo. J. Biol. Chem.
H. C. Chiou, M. V. Tangco, S. M. Levine, D. Robertson, K. Kormis, C. H. Wu, and G. Y. Wu. Enhanced resistance to nuclease degradation of nucleic acids complexed to asialoglycoprotein-polylysine carriers. Nucleic Acids Res.
C. Plank, K. Zatloukal, M. Cotten, K. Mechtler, and E. Wagner. Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand. Bioconjug. Chem.
P. Midoux, C. Mendes, A. Legrand, J. Raimond, R. Mayer, M. Monsigny, and A. C. Roche. Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells. Nucleic Acids Res.
A. A. Rosenkranz, S. V. Yachmenev, D. A. Jans, N. V. Serebryakova, V. I. Murav'ev, R. Peters, and A. S. Sobolev. Receptor-mediated endocytosis and nuclear transport of a transfecting DNA construct. Exp. Cell. Res.
T. Ferkol, J. C. Perales, F. Mularo, and R. W. Hanson. Receptor mediated gene transfer into macrophages. Proc. Natl. Acad. Sci. USA
T. Ferkol, C. S. Kaetzel, and P. B. Davis. Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglo-buline receptor. J. Clin. Invest.
V. S. Trubetskoy, V. P. Torchilin, S. J. Kennel, and L. Huang. Use of N-terminal modified poly(L-lysine)-antibody conjugate as a carrier for targeted gene delivery in mouse lung endothelial cells. Bioconjug. Chem.
J. B. Chen, S. Gamou, A. Takayanagi, and N. Shimizu. A novel gene delivery system using EGF receptor-mediated endocytosis. FEBS Lett.
E. Wagner, M. Zenke, M. Cotten, H. Beug, and M. L. Birnstiel. Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proc. Natl. Acad. Sci. USA
E. Wagner, C. Plank, K. Zatloukal, M. Cotten, and M. L. Birnstiel. Influenza-virus hemagglutinin-HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like genetransfer vehicle. Proc. Natl. Acad. Sci. USA
M. S. Wadhwa, D. L. Knoell, A. P. Young, and K. G. Rice. Targeted gene delivery with a low molecular weight glycopeptide carrier. Bioconjug. Chem.
J. Murata, Y. Ohya, and T. Ouchi. Possibility of application of quaternary chitosan having pendant galactose residues as gene delivery tool. Carbohyd. Polym.
I. A. Simpson and S. W. Cushman. Hormonal regulation of mammalian glucose transport. Annu. Rev. Biochem.