European Journal of Epidemiology

, Volume 13, Issue 7, pp 837–840

Subtypes of Campylobacter jejuni from sporadic cases of diarrhoeal disease at different locations in England are highly diverse

  • R.J. Owen
  • E. Slater
  • D. Telford
  • T. Donovan
  • M. Barnham
Article

DOI: 10.1023/A:1007497005152

Cite this article as:
Owen, R., Slater, E., Telford, D. et al. Eur J Epidemiol (1997) 13: 837. doi:10.1023/A:1007497005152

Abstract

Serotyping (heat stable antigens) was performed on 398 strains of Campylobacter jejuni from faeces of human enteritis cases in England. Strains isolated over 12 months at three locations were heterogeneous with 33 HS serotypes represented. HS1 and HS4 complex were the predominant types (34% of all strains). The monthly strain frequency distributions were similar at the three locations. The late spring peak appeared to be associated with a rise in miscellaneous serotypes rather than with the emergence of any characteristic predominant serotype. PFGE DNA restriction profiling provided evidence of a high degree of genomic diversity within the common HS1 and HS4 complex serotypes, irrespective of the geographical source, yet some subtypes were common to more than one location. The study showed that C. jejuni strain subtypes from human enteric infections in England were highly diverse, and that HS serotyping must be combined with a more discriminatory subtyping method such as PFGE DNA profiling to provide an accurate basis for epidemiological surveillance.

Campylobacter jejuni Pulse field gel electrophoretic (PFGE) profiling Serotyping 

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • R.J. Owen
    • 1
  • E. Slater
    • 1
  • D. Telford
    • 2
  • T. Donovan
    • 3
  • M. Barnham
    • 4
  1. 1.Laboratory of Enteric PathogensCentral Public Health LaboratoryLondonUk
  2. 2.Microbiology DepartmentRoyal Lancaster InfirmaryLancasterUk
  3. 3.Public Health Laboratorythe William Harvey HospitalAshford, KentUk
  4. 4.Harrogate General HospitalHarrogate, YorkshireUk

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