European Journal of Epidemiology

, Volume 14, Issue 3, pp 225–228

Sexual and non-sexual intrafamilial spread of hepatitis C virus: Intrafamilial transmission of HCV

Authors

  • N. Saltoğlu
    • Department of Clinical Microbiology and Infectious Disease, Faculty of MedicineUniversity of Çukurova
  • Y. Taşova
    • Department of Clinical Microbiology and Infectious Disease, Faculty of MedicineUniversity of Çukurova
  • R. Burgut
  • I.H. Dündar
    • Department of Clinical Microbiology and Infectious Disease, Faculty of MedicineUniversity of Çukurova
Article

DOI: 10.1023/A:1007455509185

Cite this article as:
Saltoğlu, N., Taşova, Y., Burgut, R. et al. Eur J Epidemiol (1998) 14: 225. doi:10.1023/A:1007455509185

Abstract

The rate of intrafamilial transmission of the hepatitis C virus (HCV) was investigated in 90 family members of 41 index patients with type C chronic liver disease. Antibody to HCV (anti-HCV) was detected by the EIA method (Abbott-Axsym Sys) and Hepatitis C virus RNA, by the polymerase chain reaction (Nested PCR). We also investigated the presence of anti-HCV in 350 healthy persons (control group). The subjects in the study included 38 spouses, 45 children and others (1 relative and 6 parents). Four family members including 3/38 (7.8%) spouses and 1 sister were found to be positive for anti HCV antibodies but none had HCV RNA. Anti-HCV was not detected in the children of index patients. The prevalence of anti-HCV in the families of index patients was significantly higher than in the controls (4.3% versus 0.85%) (p = 0.0355). We concluded that the intrafamilial transmission of HCV is possible but occurs at a low rate.

Hepatitis C virusIntrafamilialTransmission

Copyright information

© Kluwer Academic Publishers 1998