Cell Biology and Toxicology

, Volume 13, Issue 4, pp 263–273

Cell-cell interactions in the regulation of the expression of hepatic enzymes

  • R. Gebhardt
  • F. Gaunitz

DOI: 10.1023/A:1007431307300

Cite this article as:
Gebhardt, R. & Gaunitz, F. Cell Biol Toxicol (1997) 13: 263. doi:10.1023/A:1007431307300


The expression of enzymes and other proteins in liver parenchyma is heterogeneous and shows distinct features depending on whether all or only a subset of hepatocytes are involved. Recent advances in the elucidation of the factors that control zonated expression have provided new insights into the regulatory mechanisms that might underlie the different patterns of heterogeneity. While humoral factors seem to play a predominant role in the dynamic adaptation of zonated expression, newly identified intrahepatic (zonation) factors might be responsible for a static dissection of the parenchyma into different expression compartments. These different principles for determining heterogeneous enzyme expression are presented and discussed for cholesterol 7α-hydroxylase and glutamine synthetase.

cell-cell interactionscholesterol 7α-hydroxylaseglutamine synthetaseheterogeneous expressionintrahepatic zonation factorsliver parenchyma

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • R. Gebhardt
    • 1
  • F. Gaunitz
    • 2
  1. 1.Physiologisch-chemisches Institut der UniversitätTübingenGermany
  2. 2.Physiologisch-chemisches Institut der UniversitätTübingenGermany