Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis Article DOI:
Cite this article as: Yang, D., Michel, L., Chaumont, JP. et al. Mycopathologia (2000) 148: 79. doi:10.1023/A:1007178924408 Abstract
Caryophyllene oxide, an oxygenated terpenoid, well known as preservative in food, drugs and cosmetics, has been tested in vitro as an antifungal against dermatophytes. Its antifungal activity has been compared to ciclopiroxolamine and sulconazole, commonly used in onychomycosis treatment and chosen because of their very different chemical structures. So, a new model has been tested, utilizing sheep hoof plates in order to simulate human nails, which are almost unobtainable for in vitro tests. Three protocols were utilized: pre-treatment. simultaneous treatment and post-treatment. Among these, the post-treatment method was the best to simulate antifungal therapy. as it permitted testing and comparing the efficiency of different antifungal drugs.
Antifungal caryophyllene oxide onychomycosis model sheep hoof plate
This revised version was published online in October 2005 with corrections to the Cover Date.
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