Journal of Neurocytology

, Volume 29, Issue 5, pp 401–410

Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury

  • Phyllis M. Wise
  • Dena B. Dubal
  • Melinda E. Wilson
  • Shane W. Rau
Article

DOI: 10.1023/A:1007169408561

Cite this article as:
Wise, P.M., Dubal, D.B., Wilson, M.E. et al. J Neurocytol (2000) 29: 401. doi:10.1023/A:1007169408561

Abstract

Many clinical studies suggest that estrogen enhances memory and cognition and protects against neurodegenerative diseases and injury associated with stroke or stress. These results are strongly supported by experiments performed in animal models using both in vivo and in vitro methods. We present here data from our lab that establishes that physiological levels of estradiol exert profound protective actions against ischemic injury. Further we will present evidence that these effects may be mediated through estrogen receptors that may influence the bcl-2 family of genes.

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Phyllis M. Wise
    • 1
  • Dena B. Dubal
    • 1
  • Melinda E. Wilson
    • 1
  • Shane W. Rau
    • 1
  1. 1.Department of Physiology, College of MedicineUniversity of KentuckyLexingtonUSA