Nerve Growth Factor Inducer, 4-Methyl Catechol, Potentiates Central Sensitization Associated with Acceleration of Spinal Glutamate Release After Mustard Oil Paw Injection in Rats
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1.In rats, injection of mustard oil (MO) into the paw caused a gradual increase in flinching of the injected paw and this algogenic behavior corresponded with an increase in the CSF-Glu level.
2.The nerve growth factor (NGF) inducer, 4-methyl catechol (4MC), enhanced the frequency of flinching and this effect was dose dependent. In addition, spinal CSF-Glu release was significantly above baseline 10 min after MO injection. In contrast, morphine (MOR) pretreatment completely blocked this behavioral and neurohumoral effect.
3.Anti-NGF paw injection attenuated the algogenic behavior and spinal Glu release otherwise observed after 4MC treatment.
4.The results demonstrated that MO-induced hyperalgesia is associated with increased CSF-Glu release and that this effect is potentiated by a NGF inducer. These data also suggest a possible involvement of NGF in the development of central sensitization after acute peripheral nociceptive stimulation.
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- Nerve Growth Factor Inducer, 4-Methyl Catechol, Potentiates Central Sensitization Associated with Acceleration of Spinal Glutamate Release After Mustard Oil Paw Injection in Rats
Cellular and Molecular Neurobiology
Volume 19, Issue 5 , pp 587-596
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- neurotrophic factor
- nerve growth factor
- 4-methyl catechol
- spinal neurotransmission
- intrathecal microdialysis
- Industry Sectors
- Author Affiliations
- 1. Department of Anesthesiology-Resuscitology, School of Allied Health Sciences, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8554, Japan
- 2. Department of Dental Anesthesiology, Kyusyu Dental College, 2-8-6 Manazuru, Kokura-kita, Kitakyusyu, 803-8580, Japan
- 3. Department of Pathophysiology, Yamaguchi Prefectural University, 3-2-1, Sakurabata, Yamaguchi, 753-8502, Japan