Molecular and Cellular Biochemistry

, Volume 174, Issue 1, pp 305-319

First online:

Reactive oxygen species, mitochondria, apoptosis and aging

  • S. PapaAffiliated withInstitute of Medical Biochemistry and Chemistry, University of Bari
  • , V.P. SkulachevAffiliated withA.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


In this paper, we shall review various antioxygen defense systems of the cell paying particular attention to those that prevent superoxide formation rather than scavenge already formed superoxide and its products. The role of uncoupled, decoupled and non-coupled respiration, mitochondrial pore, mitochondrion-linked apoptosis will be considered. Mitochondrial theory of aging will be regarded in context of reactive oxygen species-induced damage of mitochondrial DNA. (Mol Cell Biochem 174: 305–319, 1997)

mitochondrial metabolism mitochondrial DNA superoxide radicals