Molecular and Cellular Biochemistry

, Volume 182, Issue 1, pp 169–175

TNF-α and insulin resistance: Summary and future prospects

  • Pascal Peraldi
  • Bruce Spiegelman

DOI: 10.1023/A:1006865715292

Cite this article as:
Peraldi, P. & Spiegelman, B. Mol Cell Biochem (1998) 182: 169. doi:10.1023/A:1006865715292


While the causes of obesity remain elusive, the relationship between obesity and insulin resistance is a well-established fact [1]. Insulin resistance is defined as a smaller than normal response to a certain dose of insulin, and contributes to several pathological problems of obese patients such as hyperlipidemia, arteriosclerosis and hypertension. Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-α) is an important player in the state of insulin resistance observed during obesity. In this review we will try to summarize what is known about the function of TNF-a in insulin resistance during obesity and how TNF-α interferes with insulin signaling.

insulin resistanceTNF-αobesityinsulin signalingadipocyteIRS-1

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Pascal Peraldi
    • 1
  • Bruce Spiegelman
    • 1
  1. 1.Dana Farber Cancer InstituteHarvard Medical SchoolBostonUSA