TNF-α and insulin resistance: Summary and future prospects
- Cite this article as:
- Peraldi, P. & Spiegelman, B. Mol Cell Biochem (1998) 182: 169. doi:10.1023/A:1006865715292
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While the causes of obesity remain elusive, the relationship between obesity and insulin resistance is a well-established fact . Insulin resistance is defined as a smaller than normal response to a certain dose of insulin, and contributes to several pathological problems of obese patients such as hyperlipidemia, arteriosclerosis and hypertension. Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-α) is an important player in the state of insulin resistance observed during obesity. In this review we will try to summarize what is known about the function of TNF-a in insulin resistance during obesity and how TNF-α interferes with insulin signaling.