Molecular and Cellular Biochemistry

, Volume 179, Issue 1, pp 159–168

Cytokines in exertion-induced skeletal muscle injury

  • Joseph G. Cannon
  • Barbara A. St. Pierre

DOI: 10.1023/A:1006828425418

Cite this article as:
Cannon, J.G. & St. Pierre, B.A. Mol Cell Biochem (1998) 179: 159. doi:10.1023/A:1006828425418


Cytokines are a diverse family of intercellular signaling proteins that influence the movement, proliferation, differentiation, metabolism and membrane processes of target cells. Synthesis and release of cytokines from leukocytes in response to microbial stimuli are well known. This review, however, will present evidence that non-infectious stimuli can induce cytokine secretion from leukocytes and other cells (including muscle cells) following myocellular injury. The biological actions and potential adaptive values of these cytokines through the course of muscle necrosis and regeneration will be described.

skeletal musclecytokinestumour necrosis factorleukocytefibroblastsneutrophilsnecrosisregenerationexercise

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Joseph G. Cannon
    • 1
  • Barbara A. St. Pierre
    • 1
  1. 1.Intercollege Physiology Program and Department of KinesiologyPennsylvania State UniversityUSA