Molecular and Cellular Biochemistry

, Volume 181, Issue 1, pp 71–76

Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats


  • Pandarinathan Chithra
    • Department of Biochemistry, Central Leather Research Institute
  • G.B. Sajithlal
    • Department of Biochemistry, Central Leather Research Institute
  • Gowri Chandrakasan
    • Department of Biochemistry, Central Leather Research Institute

DOI: 10.1023/A:1006813510959

Cite this article as:
Chithra, P., Sajithlal, G. & Chandrakasan, G. Mol Cell Biochem (1998) 181: 71. doi:10.1023/A:1006813510959


Wound healing is a fundamental response to tissue injury that results in restoration of tissue integrity. This end is achieved mainly by the synthesis of the connective tissue matrix. Collagen is the major protein of the extracellular matrix, and is the component which ultimately contributes to wound strength. In this work, we report the influence of Aloe vera on the collagen content and its characteristics in a healing wound. It was observed that Aloe vera increased the collagen content of the granulation tissue as well as its degree of crosslinking as seen by increased aldehyde content and decreased acid solubility. The type I/type III collagen ratio of treated groups were lower than that of the untreated controls, indicating enhanced levels of type III collagen. Wounds were treated either by topical application or oral administration of Aloe vera to rats and both treatments were found to result in similar effects.

collagenwound healingAloe veracrosslinking

Copyright information

© Kluwer Academic Publishers 1998