Journal of Neuro-Oncology

, Volume 50, Issue 1, pp 149–163

Anti-angiogenic Treatment Strategies for Malignant Brain Tumors

  • Matthias Kirsch
  • Gabriele Schackert
  • Peter McL. Black
Article

DOI: 10.1023/A:1006487412567

Cite this article as:
Kirsch, M., Schackert, G. & Black, P.M. J Neurooncol (2000) 50: 149. doi:10.1023/A:1006487412567

Abstract

The use of angiogenesis inhibitors may offer novel strategies in brain tumor therapy. In contrast to traditional cancer treatments that attack tumor cells directly, angiogenesis inhibitors target at the formation of tumor-feeding blood vessels that provide continuous supply of nutrients and oxygen.

With respect to brain tumor therapy, inhibitors of angiogenesis display unique features that are unknown to conventional chemotherapeutic agents. The most important features are independence of the blood–brain barrier, cell type specificity, and reduced resistance. Malignant brain tumors, especially malignant gliomas, are among the most vascularized tumors known. Despite multimodal therapeutic approaches, the prognosis remains dismal. Thus, angiogenesis inhibitors may be highly effective drugs against these tumors. In a clinical setting, they could be applied in the treatment of multiple tumors or postsurgically as an adjuvant therapy to prevent recurrence.

This article provides an overview of current anti-angiogenic treatment strategies with emphasis on substances already in clinical trials or candidate substances for clinical trials. The cellular and molecular basis of these substances is reviewed.

Angiogenesisbrain tumorgliomaclinical trials

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Matthias Kirsch
    • 1
  • Gabriele Schackert
    • 1
  • Peter McL. Black
    • 2
  1. 1.Klinik und Poliklinik für NeurochirurgieTechnische Universität DresdenGermany
  2. 2.NeurosurgeryChildren's HospitalBostonUSA