Veterinary Research Communications

, Volume 24, Issue 3, pp 143–151

Effect of Vaccination with Brucella abortus Strain RB51 on Heifers and Pregnant Cattle

  • F.A. Uzal
  • L. Samartino
  • G. Schurig
  • A. Carrasco
  • K. Nielsen
  • R.F. Cabrera
  • H.R. Taddeo
Article

DOI: 10.1023/A:1006468713614

Cite this article as:
Uzal, F., Samartino, L., Schurig, G. et al. Vet Res Commun (2000) 24: 143. doi:10.1023/A:1006468713614

Abstract

Thirteen cows, which had been vaccinated as calves with strain 19, were revaccinated twice or three times as adults with 1×109 cfu of B. abortus strain RB51. Their serological responses following adult vaccination remained negative to conventional brucellosis surveillance tests. Vaccination with strain RB51 during the eighth month of pregnancy did not induce abortion, although strain RB51 was recovered from milk for up to 69 days after vaccination. In a parallel study, thirteen 8- to 10-month-old heifers were vaccinated as calves with 109 cfu of strain RB51. The heifers remained seronegative to conventional brucellosis surveillance tests but antibody responses to RB51 could be demonstrated using an indirect ELISA. This study showed that multiple vaccination with strain RB51 did not induce seroconversion to brucellosis surveillance tests. In addition, this study suggests that 109 cfu of strain RB51 is safe for use in pregnant cattle.

brucellosis cattle safety seroconversion vaccine 

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • F.A. Uzal
    • 1
  • L. Samartino
    • 2
  • G. Schurig
    • 3
  • A. Carrasco
    • 1
  • K. Nielsen
    • 4
  • R.F. Cabrera
    • 1
  • H.R. Taddeo
    • 5
  1. 1.Animal Health UnitThe National Institute of Agricultural Technology (INTA)BarilocheArgentina
  2. 2.Research Center on Veterinary SciencesThe National Institute of Agricultural Technology (INTA), MoronBuenos AiresArgentina
  3. 3.Virginia Maryland Regional College of Veterinary MedicineVirginia TechBlacksbergUSA
  4. 4.Canada
  5. 5.Biometry SectionThe National Institute of Agricultural Technology (INTA)BarilocheArgentina