Journal of Neuro-Oncology

, Volume 50, Issue 1, pp 109–120

VEGF in Brain Tumors

  • Marcia Regina Machein
  • Karl Heinz Plate

DOI: 10.1023/A:1006416003964

Cite this article as:
Machein, M.R. & Plate, K.H. J Neurooncol (2000) 50: 109. doi:10.1023/A:1006416003964


Vascular endothelial growth factor (VEGF) is a regulator of angiogenesis, vasculogenesis and vascular permeability. In this contribution, molecular and biological properties of VEGF are described. Furthermore, this article focuses on the evidence that angiogenesis in brain tumors is mediated by VEGF. Among the topics discussed are expression patterns of VEGF and its receptors in different brain tumors, possible regulatory mechanism involved in the VEGF-driven tumor angiogenesis and the involvement of VEGF in the genesis of peritumoral edema. Finally, anti-angiogenesis approaches to target VEGF/VEGF receptors are discussed.

VEGFVEGF receptorsangiogenesisbrain tumorsbrain edema

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Marcia Regina Machein
    • 1
  • Karl Heinz Plate
    • 2
  1. 1.Department of NeurosurgeryNeurocenter, Freiburg University Medical SchoolFreiburg
  2. 2.Department of NeuropathologyErlangen-Nürnberg University Medical SchoolErlangenGermany