Sequential Histopathology at the Rhipicephalus Sanguineus Tick Feeding Site on Dogs and Guinea Pigs
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The tick Rhipicephalus sanguineus is a very common parasite of dogs worldwide. Dogs seem unable to acquire resistance against this tick species, whereas guinea pigs demonstrate a very strong resistance following primary infestation. We studied the inflammatory reaction at the R. sanguineus tick feeding site on dogs and guinea pigs during primary and tertiary infestations at different time intervals after attachment. Biopsies were collected after 4, 24, 48 and 96 hours. Changes that were found in all experimental groups included a cone of cement around the mouthparts of the tick, epidermal hyperplasia, edema and inflammatory cell infiltration in the dermis directly underneath the tick attachment site. Dogs reacted to ticks mainly with neutrophils, particularly after repeated exposure. Mast cells and mononuclear leukocytes were also present. Guinea pigs reacted to R. sanguineus mainly with mononuclear cells, eosinophils and basophils. These cells were particularly numerous after repeated exposure to R. sanguineus. Our results suggest that basophils and eosinophils are involved in resistance of guinea pigs to R. sanguineus and that neutrophils in dogs have little effect against this tick species.
- Bechara, G.H., Szabó, M.P.J., Mukai, L.S. and Rosa, P.C.S. 1994. Immunisation of dogs, hamsters and guinea pigs against Rhipicephalus sanguineus using crude unreleased adult tick extracts. Vet. Parasitol. 52: 79–90.
- Brown, S.J., Galli, J.S., Gleich, G.J. and Askenase, P.W. 1982. Ablation of immunity to Amblyomma americanum by anti-basophil serum: cooperation between basophils and eosinophils in expression of immunity to ectoparasites (ticks) in guinea-pigs. J. Immunol. 129(2): 790–796.
- Chabaud, A.G. 1950. L'infestation par des ixodinés provoque-t-elle une immunité chez l-hôte (2me note). Ann. Parasitol. 25(5–6): 474–479.
- Comer, K.M. 1988. Carpet deodorizer as a contact allergen in a dog. J.A.V.M.A. 193: 1553–1554.
- Cotran, R.S., Kumar, V. and Robbins, S.L. 1994. Inflammation and Repair. In: Robbins Pathologic Basis of Disease, R.S. Cotran, V. Kumar and S.L. Robbins (eds). W.B. Saunders Company, 5th ed.
- Dumler, J.S. and Bakken, J.S. 1998. Human ehrlichioses: newly recognized infections transmitted by ticks. Annual Ver. Med. 49: 201–213.
- Fielden, L.J., Rechav, Y. and Bryson, N.R. 1992. Acquired immunity to larvae of Amblyomma marmoreum and A. hebraeum by tortoises, guinea-pigs and guinea-fowl. Med. Vet. Entomol. 6: 251–254.
- Freitas, M.G., Costa, H.M.A., Costa, J.O. and Iide, P. 1978. Entomologia e Acarologia Médica e Veterinária. Editora Rabelo e Brasil, Belo Horizonte, Brasil.
- Galkowska, H. and Olszewski, W.L. 1986. Cellular composition of lymph in experimental lymphedema. Lymphology 19: 139–145.
- Galkowska, H., Dabrowski, M. and Olszewski, W.L. 1989. Spontaneously active suppressive cells in the canine peripheral blood. Vet. Immunol. Immunopathol. 20: 101–108.
- Giorgi, R., Pagano, R.L., Dias, M.A., Aguiar-Passeti, T., Sorg, C. and Mariano, M. 1998. Antinociceptive effect of the calcium-binding protein MRP-14 and the role played by neutrophils on the control of inflammatory pain. J. Leukoc. Biol. 64(2): 214–220.
- Halliwell, R.E.W. and Schemmer, R.K. 1987 The role of basophils in the immunopathogenesis of hypersensitivity to fleas (Ctenocephalides felis) in dogs. Vet. Immunol. Immunopathol.15: 203–13.
- Inokuma, H., Hara, Y., Aita, T. and Onishi, T. 1997. Effect of infestation with Rhipicephalus sanguineus on neutrophil function in dogs. Med. Vet. Entomol. 11: 401–403.
- Jain, N.C. 1986. The neutrophils. In: Schalm's Veterinary Hematology, 4th Edn, pp. 676–730. Lea and Feibiger Press, Philadelphia.
- Lloyd, A.R. and Oppenheim, J.J. 1992. Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response. Immunol. Today 13(5): 169–172.
- Luft, J.H. 1961. Improvements in epoxi resin embedding methods. J. Biochem. Cytol. 9: 409–417.
- Moller, A., Lippert, U., Lessmann, D., Kolde, G., Hamann, K., Welker, P., Schadendorf, D., Rosenbach, T., Luger, T. and Czarnetzki, B.M. 1993. Human mast cells produce Il-8. J. Immunol. 151(6): 3261–3266.
- Paine, S.H., Kemp, D.H. and Allen, J.R. 1983. In vitro feeding of Dermacentor andersoni (Stiles): effects of histamine and other mediators. Parasitology 86: 419–428.
- Pegram, R.G., Clifford, C.M., Walker, J.B. and Keirans, J.E. 1987. Clarification of the Rhipicephalus sanguineus group (Acari, Ixodoidea, Ixodidae). I. R. sulcatus (Neuman, 1908) and R. turanicus (Pomerantsev, 1936). Sys. Parasitol 10: 3–26.
- Randolph, S.E. 1979. Population regulation in ticks: the role of acquired resistance in natural and unnatural hosts. Parasitology 79: 141–156.
- Rechav, Y. 1992. Naturally acquired resistance to ticks — a global view. Insect. Sci. Applic. 13(4): 405–504.
- Ribeiro, J.M.C. 1989. Role of saliva in tick/host interactions. Exp. Appl. Acarol. 7: 15–20.
- Ribeiro, J.M.C., Weiss, J.J. and Telford III, S.R. 1990. Saliva of the tick Ixodes dammini inhibits neutrophil function. Exp. Parasitol. 70: 382–8.
- Scepek, S., Moqbel, R. and Lindau, M. 1994. Compound exocytosis and cumulative degranulation by eosinophils and their role in parasite killing. Parasitol. Today 10(7): 276–278.
- Szabó, M.P.J. and Bechara, G.H. 1995. An insight into the histopathology caused by the tick Rhipicephalus sanguineus (Acarina: Ixodidae) in the skin of previously infested, vaccinated or tick-bite naive dogs, guinea pigs and hamsters. Braz. J. vet. Res. anim. Sci. 32(1): 37–42.
- Szabó, M.P.J., Morelli Jr., J. and Bechara, G.H. 1995a. Cutaneous hypersensitivity induced in dogs and guinea pigs by extracts of the tick Rhipicephalus sanguineus (Acari: Ixodidae). Exp. Appl. Acarol. 19: 723–730.
- Szabó, M.P.J., Mukai, L.S., Rosa, P.C.S. and Bechara, G.H. 1995b. Differences in the acquired resistance of dogs, hamsters, and guinea pigs to repeated infestations with adult ticks Rhipicephalus sanguineus (Acari: Ixodidae). Braz. J. vet. Res. anim. Sci. 32(1): 43–50.
- Theis, J.H. and Budwiser, P.D. 1974. Rhipicephalus sanguineus: sequential histopathology at the hostarthropode interface. Exp. Parasitol. 36: 77–105.
- Walker, A.R. and Fletcher, J.D. 1986. Histological study of the attachment sites of adult Rhipicephalus appendiculatus on rabbits and cattle. Int. J. Parasitol. 16: 399–413.
- Wikel, S.K. 1996. Immunology of the tick-host interface. In: The immunology of Host-ectoparasitic arthropod relationships, S.K. Wikel (ed.), pp. 204–231. Cab International, UK. pp. 204–231.
- Weiss, S.J. 1989. Tissue destruction by neutrophils. N. Engl. J. Med. 320(6): 365–376.
- Zucker-Franklin, D. 1990. Eosinophils: Morphology, production, chemistry and function. In: Hematology, W.J. Williams, E. Beutler, A.J. Erslev and M.A. Lichtman, (eds), 4th edn, pp. 835–855. McGraw-Hill, Inc.
- Sequential Histopathology at the Rhipicephalus Sanguineus Tick Feeding Site on Dogs and Guinea Pigs
Experimental & Applied Acarology
Volume 23, Issue 11 , pp 915-928
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