Investigational New Drugs

, Volume 17, Issue 4, pp 375-386

First online:

Oncolytic Viruses

  • John Nemunaitis

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Viruses capable of inducing lysis of malignant cells through theirreplication process are known as ``oncolytic'' viruses. Clinicaltrials in oncology have been performed with oncolytic viruses fornearly fifty years. Both systemic and intratumoral routes ofadministration have been explored. Toxicity has generally beenlimited to injection site pain, transient fever and tumor necrosis.Responses with early crude materials were usually short induration; however, recent trials with gene attenuated virusessuggest more prolonged duration to responses observed.

viruses oncolytic lysis malignant