Cancer and Metastasis Reviews

, Volume 17, Issue 3, pp 279–284

Orthotopic Models are Necessary to Predict Therapy of Transplantable Tumors in Mice

  • Jerald J. Killion
  • Robert Radinsky
  • Isaiah J. Fidler
Article

DOI: 10.1023/A:1006140513233

Cite this article as:
Killion, J.J., Radinsky, R. & Fidler, I.J. Cancer Metastasis Rev (1998) 17: 279. doi:10.1023/A:1006140513233

Abstract

Rapid evaluation of new cytotoxic agents and biological response modifiers for therapy of cancer and elucidation of their mechanisms of action require the use of relevant animal models. It is well established that the faithful reproduction of the tumor microenvironment that allows the emergence of subpopulations of tumor cells with the biological and metastatic properties observed in clinical cancer occurs with orthotopic tumor models (transplantable and transgenic). This review summarizes the evidence that phenotypic properties of metastatic cells are governed by the expression of genes that are regulated by interaction with the relevant organ environment. While ectopic models of cancer allow rapid screening of new compounds and transgenic models afford opportunities to study early cellular and molecular events in tumor progression and metastasis, orthotopic transplantation of tumor cells remains an affordable, reproducible and reliable methodology for the study of organ-specific determinants of the biology and therapy of cancer.

metastasis tumor model orthotopic implantation organ-specific 

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Jerald J. Killion
    • 1
  • Robert Radinsky
    • 1
  • Isaiah J. Fidler
    • 1
  1. 1.Department of Cell BiologyThe University of Texas, M.D. Anderson Cancer CenterHoustonUSA

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