Breast Cancer Research and Treatment

, Volume 49, Issue 2, pp 109–117

Effect of antiprogestins and tamoxifen on growh inhibition of MCF-7 human breast cancer cells in nude mice

  • M. Fathy El Etreby
  • Yayun Liang

DOI: 10.1023/A:1006098910000

Cite this article as:
Etreby, M.F.E. & Liang, Y. Breast Cancer Res Treat (1998) 49: 109. doi:10.1023/A:1006098910000


This is the first report demonstrating an in vivo antitumor activity of antiprogestins (mifepristone, onapristone) alone and in combination with tamoxifen in the MCF-7 human breast cancer model. The MCF-7 cells produced progressive growing tumors in female nude mice supplemented with 17β-estradiol. Tumor regression was observed following either estrogen ablation alone or estrogen ablation in combination with tamoxifen. Monotherapy with tamoxifen or antiprogestins caused a retardation of estrogen-induced tumor progression. Complete inhibition or prevention of tumor growth occurred as a result of simultaneous administration of mifepristone and tamoxifen. The addition of mifepristone in this combination treatment was also effective in delaying or preventing tumor escape (relapse) from the antiestrogenic (antitumor) effect of tamoxifen. These results suggest a potential clinical benefit of adding an antiprogestin to antiestrogen therapy of breast cancer patients.

antiestrogens (tamoxifen)antiprogestins (mifepristone, onapristonebreast cancerMCF-7 cellsnude mice

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • M. Fathy El Etreby
    • 1
  • Yayun Liang
    • 1
  1. 1.Department of SurgeryMedical College of GeorgiaAugustaUSA