Journal of Neuro-Oncology

, Volume 38, Issue 1, pp 51–57

The effect of the anti-angiogenic agent TNP-470 on tumor growth and vascularity in low passaged xenografts of human gliomas in nude mice

  • H.J.J.A. Bernsen
  • P.F.J.W. Rijken
  • H. Peters
  • H. Bakker
  • A.J. van der Kogel
Article

DOI: 10.1023/A:1005957201431

Cite this article as:
Bernsen, H., Rijken, P., Peters, H. et al. J Neurooncol (1998) 38: 51. doi:10.1023/A:1005957201431

Abstract

The effect of the anti-angiogenic agent TNP-470 on tumor growth, vascular area, vascular density and tumor perfusion of two different subcutaneously implanted human glioma xenografts (E98 and E106) in nude mice was evaluated. Vascular parameters were investigated with an image analysis system. For both tumor lines a small but significant tumor growth suppression was observed. However, no differences in vascular parameters between TNP-470 treated tumors and controls could be found after 6 weeks of treatment. It is concluded that although TNP-470 is a promising anti-angiogenic agent in many tumor types, at least 2 glioma lines seem to be partly resistant to its anti-angiogenic effects. Further evaluation of the effects of combination of TNP-470 and cytostatic agents or radiotherapy in human glioma xenografts are required to determine the place of anti-angiogenic therapy in general and treatment with the anti-angiogenic agent TNP-470 more specifically in the treatment of human gliomas.

TNP-470gliomanude micequantitative vascular analysis

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • H.J.J.A. Bernsen
    • 1
    • 2
  • P.F.J.W. Rijken
    • 1
  • H. Peters
    • 1
  • H. Bakker
    • 3
  • A.J. van der Kogel
    • 1
  1. 1.Institute of RadiotherapyUniversity of NijmegenThe Netherlands
  2. 2.Department of NeurologyCanisius-Wilhelmina HospitalNijmegen, The Netherlands
  3. 3.Department of PharmacologyUniversity of NijmegenThe Netherlands