Biotechnology Letters

, Volume 22, Issue 22, pp 1793–1796

Intermittent maltose feeding enhances paclitaxel production in suspension culture of Taxus chinensis cells

  • Hyung-Kyoon Choi
  • Sang-Ic Kim
  • Joo-Sun Son
  • Seung-Suh Hong
  • Hyun-Soo Lee
  • In-Sik Chung
  • Hyong-Joo Lee
Article

DOI: 10.1023/A:1005658405449

Cite this article as:
Choi, HK., Kim, SI., Son, JS. et al. Biotechnology Letters (2000) 22: 1793. doi:10.1023/A:1005658405449

Abstract

High paclitaxel production (26 mg l−1) was achieved through the intermittent feeding of 3, 1, and 2% (w/v) sucrose at days 0, 7, and 21, respectively, to a suspension culture of Taxus chinensis cells. Intermittent feedings of 1 and 2% (w/v) maltose at days 7 and 21, respectively, to the culture increased the paclitaxel production up to 67 mg l−1.

intermittent feedingmaltosepaclitaxelTaxus chinensis

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Hyung-Kyoon Choi
    • 1
  • Sang-Ic Kim
    • 1
  • Joo-Sun Son
    • 1
  • Seung-Suh Hong
    • 1
  • Hyun-Soo Lee
    • 1
  • In-Sik Chung
    • 2
  • Hyong-Joo Lee
    • 3
  1. 1.Samyang Genex Biotech Research InstituteTaejonKorea
  2. 2.Department of Genetic EngineeringKyung Hee UniversitySuwonKorea
  3. 3.Department of Food Science and Technology, School of Agricultural BiotechnologySeoul National UniversitySuwonKorea