Digestive Diseases and Sciences

, Volume 46, Issue 3, pp 644–648

Predictive Value of Inflammatory and Coagulation Parameters in the Course of Severe Ulcerative Colitis

  • Authors
  • R.K. Linskens
  • A.A. Van Bodegraven
  • M. Schoorl
  • H.A.R.E. Tuynman
  • P. Bartels

DOI: 10.1023/A:1005628005734

Cite this article as:
Linskens, R., Van Bodegraven, A., Schoorl, M. et al. Dig Dis Sci (2001) 46: 644. doi:10.1023/A:1005628005734


Alterations in markers of coagulation have been found in patients with inflammatory bowel disease. Our aim was to study the predictive value of coagulation and inflammatory parameters in the course of severe ulcerative colitis. Twenty-seven patients were included. The disease course was followed for one year. Sensitivity, specificity, negative predictive value, positive predictive value, and likelihood ratio, as well as the clinical predictive value of laboratory variables were calculated. Inflammatory variables, such as ESR, CRP, and leukocyte and platelet count showed poor diagnostic accuracy. Several coagulation parameters, such as fibrinogen and fibrin(ogen) degradation products, were increased in patients with active ulcerative colitis, whereas coagulation factor XIII was decreased. No significant relationship between clinical course and coagulation parameters was demonstrated, though both inflammatory and coagulation parameters were useful in the assessment of disease activity in patients with active ulcerative colitis.

ulcerative colitisacute phase proteinscoagulationfibrin degradation productsfactor XIIIfibrinolysis

Copyright information

© Plenum Publishing Corporation 2001