Journal of Bioenergetics and Biomembranes

, Volume 32, Issue 3, pp 301–308

Nm23/Nucleoside Diphosphate Kinase in Human Cancers

  • Melanie T. Hartsough
  • Patricia S. Steeg
Article

DOI: 10.1023/A:1005597231776

Cite this article as:
Hartsough, M.T. & Steeg, P.S. J Bioenerg Biomembr (2000) 32: 301. doi:10.1023/A:1005597231776

Abstract

Tumor metastasis is the leading cause of death in cancer patients. From a series of tumorcohort studies, low expression of Nm23/NDP kinase has been correlated with poor patientprognosis and survival, lymph node infiltration, and histopathological indicators of highmetastatic potential in a number of cancer types, including mammary and ovarian carcinomas andmelanoma. In other tumor types, no correlation has been established. Transfection ofNm23/NDP kinase cDNA into highly metastatic breast, melanoma, prostrate and squamous cellcarcinomas, and colon adenocarcinoma cells significantly reduced the metastatic competencyof the cells in vivo. In culture, cell motility, invasion, and colonization were inhibited, whereastumorigenicity and cellular proliferation were not affected, indicating that Nm23/NDP kinaseacts as a metastasis suppressor.

NDP kinaseNm23loss of heterozygositymetastasis suppressorNME genes

Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Melanie T. Hartsough
    • 1
  • Patricia S. Steeg
    • 2
  1. 1.Laboratory of Pathology, National Cancer InstituteNational Institutes of HealthBethesda
  2. 2.Laboratory of Pathology, National Cancer InstituteNational Institutes of HealthBethesda