Journal of Bioenergetics and Biomembranes

, Volume 32, Issue 3, pp 269–275

NM23/Nucleoside Diphosphate Kinase and Signal Transduction

  • Angela de S. Otero

DOI: 10.1023/A:1005589029959

Cite this article as:
Otero, A.d.S. J Bioenerg Biomembr (2000) 32: 269. doi:10.1023/A:1005589029959


NM23s (or NDP kinases) regulate a fascinating variety of cellular activities, includingproliferation, development, and differentiation. All these processes are modulated by external stimuli,leading to the idea that this family of proteins modulates transmembrane signaling pathways.This review summarizes the evidence indicating that NM23/NDP kinases participate intransmembrane signaling in eukaryotic cells and discusses the molecular mechanisms proposed toaccount for these actions.

Nucleoside diphosphate kinasenm23signal transductioncytoskeletonreceptorsGTP binding proteinsphosphorylation

Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Angela de S. Otero
    • 1
  1. 1.Department of Molecular Physiology and Biological PhysicsUniversity of Virginia Medical SchoolCharlottesville