Journal of Bioenergetics and Biomembranes

, Volume 32, Issue 3, pp 293–300

Role of AWD/Nucleoside Diphosphate Kinase in Drosophila Development

  • Lisa Timmons
  • Allen Shearn

DOI: 10.1023/A:1005545214937

Cite this article as:
Timmons, L. & Shearn, A. J Bioenerg Biomembr (2000) 32: 293. doi:10.1023/A:1005545214937


The abnormal wing discs gene of Drosophila encodes a soluble protein with nucleosidediphosphate kinase activity. This enzymic activity is necessary for the biological function ofthe abnormal wing discs gene product. Complete loss of function, i.e., null, mutations causelethality after the larval stage. Most larval organs in such null mutant larvae appear to benormal, but the imaginal discs are small and incapable of normal differentiation.Killer-of-prune is a neomorphic mutation in the abnormal wing discs gene. It causes dominant lethalityin larvae that lack prune gene activity. The Killer-of-prune mutant protein may have alteredsubstrate specificity. Null mutant larvae have a low level of nucleoside diphosphate kinaseactivity. This suggests that there may be additional Drosophila genes that encode proteinswith nucleoside dipthosphate kinase activity. Candidate genes have been found in theDrosophila genome.

abnormal wing discslethal mutantDrosophilaKiller-of-pruneprune

Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Lisa Timmons
    • 1
  • Allen Shearn
    • 2
  1. 1.Department of EmbryologyCarnegie Institution of WashingtonBaltimore
  2. 2.Department of BiologyThe Johns Hopkins UniversityBaltimore