Article

Digestive Diseases and Sciences

, Volume 45, Issue 4, pp 809-818

First online:

Upper Gastrointestinal Symptoms in North America

  • Lori FrankAffiliated withCenter for Health Outcomes Research, MEDTAP International, Inc.Gastroenterology Section, Veteran's Administration Medical CenterJanssen Research FoundationJanssen Ortho Inc.Intestinal Disease Research Programme, Division of Gastroenterology, McMaster University
  • , Leah KleinmanAffiliated withCenter for Health Outcomes Research, MEDTAP International, Inc.Gastroenterology Section, Veteran's Administration Medical CenterJanssen Research FoundationJanssen Ortho Inc.Intestinal Disease Research Programme, Division of Gastroenterology, McMaster University
  • , Dara GanoczyAffiliated withCenter for Health Outcomes Research, MEDTAP International, Inc.Gastroenterology Section, Veteran's Administration Medical CenterJanssen Research FoundationJanssen Ortho Inc.Intestinal Disease Research Programme, Division of Gastroenterology, McMaster University
  • , Kenneth McquaidAffiliated withCenter for Health Outcomes Research, MEDTAP International, Inc.Gastroenterology Section, Veteran's Administration Medical CenterJanssen Research FoundationJanssen Ortho Inc.Intestinal Disease Research Programme, Division of Gastroenterology, McMaster University
  • , Sheldon SloanAffiliated withCenter for Health Outcomes Research, MEDTAP International, Inc.Gastroenterology Section, Veteran's Administration Medical CenterJanssen Research FoundationJanssen Ortho Inc.Intestinal Disease Research Programme, Division of Gastroenterology, McMaster University
  • , Andrew EgglestonAffiliated withCenter for Health Outcomes Research, MEDTAP International, Inc.Gastroenterology Section, Veteran's Administration Medical CenterJanssen Research FoundationJanssen Ortho Inc.Intestinal Disease Research Programme, Division of Gastroenterology, McMaster University
  • , Gervais TougasAffiliated withCenter for Health Outcomes Research, MEDTAP International, Inc.Gastroenterology Section, Veteran's Administration Medical CenterJanssen Research FoundationJanssen Ortho Inc.Intestinal Disease Research Programme, Division of Gastroenterology, McMaster University
  • , Christina FarupAffiliated withCenter for Health Outcomes Research, MEDTAP International, Inc.Gastroenterology Section, Veteran's Administration Medical CenterJanssen Research FoundationJanssen Ortho Inc.Intestinal Disease Research Programme, Division of Gastroenterology, McMaster University

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

The aim of this study was to determine the prevalence of upper gastrointestinal symptoms (UGIS) in a general population and quantify the relationship of those symptoms to health-care utilization and quality of life. In-person interviews were conducted with 2056 United States and Canadian residents selected at random. Subjects reported frequency and severity for 11 symptoms, prescription and over-the-counter medication use, primary care and specialty physician visits in prior three months, and completed the Psychological General Well-Being Scale. For analyses, subjects were classified into four mutually exclusive symptom groups: gastroesophageal reflux disease (GERD) -like, GERD plus motility-like (GERD+), ulcerlike, and motility-like. Of the total sample, 51.4% reported the occurrence of at least one UGIS in the prior three months. Subjects in the GERD+ and ulcer groups used more prescription medications and were more likely to see a physician about the symptoms (P < 0.001). Subjects with symptoms demonstrated poorer quality of life compared to subjects with no symptoms. The prevalence of UGIS in the general population is high and symptoms are associated with significant health-care utilization and poorer quality of life.

gastrointestinal symptoms ulcer gastroesophageal reflux disease health-care utilization quality of life