Journal of Autism and Developmental Disorders

, Volume 30, Issue 2, pp 121–126

Case Report: High Functioning Autism and Childhood Disintegrative Disorder in Half Brothers

  • L. Zwaigenbaum
  • P. Szatmari
  • W. Mahoney
  • S. Bryson
  • G. Bartolucci
  • J. MacLean
Article

DOI: 10.1023/A:1005455505211

Cite this article as:
Zwaigenbaum, L., Szatmari, P., Mahoney, W. et al. J Autism Dev Disord (2000) 30: 121. doi:10.1023/A:1005455505211

Abstract

Childhood Disintegrative Disorder (CDD) is grouped with autism as a subtype of Pervasive Developmental Disorder (PDD) in ICD-10 and DSM-IV. This is the first report of autism and CDD cosegregating within a sibship. J. P. and M. P. are half-brothers with the same mother. J. P. is an 18-year-old with impairments in communication, social reciprocity, and stereotypies and was diagnosed with autism. M. P. is a 7-year-old who developed normally to 2 years 4 months. He then underwent a profound regression, becoming nonverbal and socially withdrawn, and lost adaptive skills. Investigations did not reveal any neurodegenerative process. M. P. was diagnosed with CDD. The rarity of the two conditions suggests a shared transmissible mechanism. The implications for autism/PDD genetic studies are discussed.

Childhood disintegrative disorderautismhalf-brothers

Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • L. Zwaigenbaum
    • 1
  • P. Szatmari
    • 2
  • W. Mahoney
    • 3
  • S. Bryson
    • 4
  • G. Bartolucci
    • 2
  • J. MacLean
    • 2
  1. 1.Department of PediatricsMcMaster UniversityHamiltonCanada
  2. 2.Department of PsychiatryMcMaster UniversityHamiltonCanada
  3. 3.Department of PediatricsMcMaster UniversityHamiltonCanada
  4. 4.Department of PsychologyYork UniversityNorth YorkCanada