Genetica

, Volume 107, Issue 1, pp 239–248

Sectorial mutagenesis by transposable elements

  • Jerzy Jurka
  • Vladimir V. Kapitonov
Article

DOI: 10.1023/A:1003989620068

Cite this article as:
Jurka, J. & Kapitonov, V.V. Genetica (1999) 107: 239. doi:10.1023/A:1003989620068

Abstract

Transposable elements (TEs) generate insertions and cause other mutations in the genomic DNA. It is proposed that during co-evolution between TEs and eukaryotic genomes, an optimal path of the insertion mutagenesis is determined by the surviving TEs. These TEs can become semi-permanently established, chromatin-regulated ‘source’ or ‘mutator genes’, responsible for targeting insertion mutations to specific chromosomal regions. Such mutations can manifest themselves in non-random distribution patterns of interspersed repeats in eukaryotic chromosomes. In this paper we discuss specific models, examples and implications of optimized mutagenesis in eukaryotes.

transposable elementsrepetitive DNAmutagenesischromosomal evolution

Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Jerzy Jurka
    • 1
  • Vladimir V. Kapitonov
    • 1
  1. 1.Genetic Information Research InstituteSunnyvaleUSA