Skip to main content
SpringerLink
Log in

Heparin-Induced Thrombocytopenia: Patient Profiles and Clinical Manifestations

  • Published:
Journal of Thrombosis and Thrombolysis Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Bell WR, Tomasulo PA, Alving BM, Duffy TP. Thrombocytopenia occurring during the administration of heparin: a prospective study in 52 patients. Ann Intern Med 1976;85:155–160.

    Google Scholar 

  2. Nelson JC, Lerner RG, Goldstein R, Cagin NA. Heparin-induced thrombocytopenia. Arch Intern Med 1978;138:548–552.

    Google Scholar 

  3. Warkentin TE, Levin MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 1995;332:1330–1335.

    Google Scholar 

  4. Schmitt PB, Adelman B. Heparin-associated thrombocytopenia: a critical review and a pooled analysis. Am J Med Sci 1993;305:208–215.

    Google Scholar 

  5. Warkentin TE, Kelton JG. A 14-year study of heparin-induced thrombocytopenia. Am J Med 1996;101:502–507.

    Google Scholar 

  6. Arnout J. The Pathogenesis of the antiphospholipid syndrome: a hypothesis based on parallelisms with heparin-induced thrombocytopenia. Thromb & Haemost 1996;75:536–541.

    Google Scholar 

  7. Chong BH, Murray B, Berndt MC, Dunlop LC, Brighton T, Chesterman CN. Plasma P-selectin is increased in thrombotic consumptive platelet disorders. Blood 1994;83:1535–1541.

    Google Scholar 

  8. Warkentin TE, Hayward CPM, Boshkov LK, et al. Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: an explanation for the thrombotic complications of heparin-induced thrombocytopenia. Blood 1994;84:3691–3699.

    Google Scholar 

  9. Cines DB, Tomaski A, Tannenbaum S. Immune endothelial-cell injury in heparin-associated thrombocytopenia. N Engl J Med 1987;316:581–589.

    Google Scholar 

  10. Hach-Wunderle V, Kainer K, Krug B, Müller-Berghaus G, Pötzsch B. Heparin-associated thrombosis despite normal platelet counts (letter). Lancet 1994;344:469–470.

    Google Scholar 

  11. Warkentin TE. Heparin-induced skin lesions. Br J Haematol 1996;92:494–497.

    Google Scholar 

  12. Towne JB, Bernhard VM, Hussey C, et al. White clot syndrome. Peripheral vascular complications of heparin therapy. Arch Surg 1979;114:372–377.

    Google Scholar 

  13. Benhamou AC, Gruel Y, Barsotti J, et al. The white clot syndrome or heparin associated thrombocytopenia and thrombosis (WCS or HATT): (26 cases). Int Angiol 1985;4:303–310.

    Google Scholar 

  14. Chang JC. White clot syndrome associated with heparin-induced thrombocytopenia: a review of 23 cases. Heart Lung 1987;16:403–407.

    Google Scholar 

  15. Boshkov LK, Warkentin TE, Hayward CPM, Andrew M, Kelton JG. Heparin-induced thrombocytopenia and thrombosis: clinical and laboratory studies. Br J Haematol 1993;84:322–328.

    Google Scholar 

  16. Kyntsis AP, Williams EL, Schutta HS. Cerebral venous thrombosis due to heparin-induced thrombocytopenia. Stroke 1990;21:1503–1505.

    Google Scholar 

  17. Arthur CK, Grant SJB, Murray WK, Isbister JP, Stiel JN, Lauer CS. Heparin-associated acute adrenal insufficiency (letter). Aust NZ J Med 1985;15:454–455.

    Google Scholar 

  18. Ernest D, Fisher MM. Heparin-induced thrombocytopenia complicated by bilateral adrenal haemorrhage. Intens Care Med 1991;17:238–240.

    Google Scholar 

  19. Warkentin TE, Elavathil LJ, Hayward CPM, Johnston MA, Russet JI, Kelton JG. The pathogenesis of venous limb gangrene associated with heparin-induced thrombocytopenia. Ann Int Med 1997;127:805–812.

    Google Scholar 

  20. Hartman AR, Hood RM, Anagnostopoulos CE. Phenomenon of heparin-induced thrombocytopenia associated with skin necrosis. J Vasc Surg 1988;7: 781–782.

    Google Scholar 

  21. Warkentin TE. Heparin-induced skin lesions. Br J Haematol 1996;92:494–497.

    Google Scholar 

  22. Warkentin TE, Soutar RL, Panju A, Ginsberg JS. Acute systemic reactions to intravenous bolus heparin therapy: characterization and relationship to heparin-induced thrombocytopenia. Immunohematology 1997;160a.

  23. Warkentin TE, Hirte HW, Anderson DR, et al. Transient global amnesia associated with acute heparin-induced thrombocytopenia. Am J Med 1994;97:489–491.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Cardiovascular Medicine, University of Massachusetts Medical Center, Massachusetts, USA

    Frederick A. Spencer

Authors
  1. Frederick A. Spencer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spencer, F.A. Heparin-Induced Thrombocytopenia: Patient Profiles and Clinical Manifestations. J Thromb Thrombolysis 10 (Suppl 1), 21–25 (2000). https://doi.org/10.1023/A:1027325002276

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1027325002276

Search

Navigation