Abstract
Cytomegalovirus infection is usually reported inimmunocompromised patients. In this study, apparentlyimmunocompetent patients with cytomegaloviral colitiswere reviewed. Records with a diagnosis ofcytomegaloviral colitis from January 1989 to June 1996 wereretrieved for analysis. Ten patients were included(median age 70 yr). The major presenting symptoms werediarrhea and hematochezia. Ulceration was the mainmacroscopic finding. Rectal bleeding was mostlyself-limiting. Three patients developed localcomplications (rectovaginal fistula in two; rectalstricture in one). In the two patients with rectovaginalfistula, lymphocytes subsets and proliferative response wereentirely normal. In the other patient, low B lymphocytecount and low response to mitogen were demonstrated.However, the immunoglobulins were not suppressed and rectal biopsies revealed noncaseatinggranulomas, suggesting activated cell-mediated immunity.In conclusion, a high index of suspicion is crucial forearly diagnosis of cytomegaloviral colitis in patients with bloody diarrhea, even though obviousevidence of immunodeficiency is lacking.
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REFERENCES
Kumar ML, Nankervis GA: Cytomegalovirus infections. South Med J 72:854–861, 1979
Stagno S: Cytomegalovirus. In Oxford Text Book of Medicine. DJ Weatherall, JGG Ledingham, DA Warrell (eds). New York, Oxford University Press, 1996, pp 359–363
Goodgane RW: Gastrointestinal cytome galovirus disease. Ann Intern Med 119:924–935, 1993
Hinnant KL, Rotterdam HZ, Bell ET, Tapper ML: Cytomegalovirus infection of the alimentary tract: A clinicopathological correlation. Am J Gastroenterol 81:944–950, 1986
Cheung ANY, Ng IOL: Cytomegalovirus infection of the gastrointestinal tract in non-AIDS patients. Am J Gastroenterol 88:1882–1886, 1993
Surawicz CM, Myerson D: Self-limited cytome galovirus colitis in immunocompetent individuals. Gastroenterology 94:194–199, 1988
Spielgel JS, Schwabe AD: Disseminated cytome galovirus infection with gastrointestinal involvement. Am J Gastroenterol 73:37–44, 1980
Maignan M, Wahl D, Thiaucourt D, Bach D, De Korwin JD, Vaillant G, Paille F, Schmitt J: Self-limited primary cytomegalovirus colitis in an immunocompetent individual. J Intern Med 232:357–359, 1992
Diepersloot RJA, Kroes ACM, Visser W, Jiwa NM, Rothbarth PH: Acute ulcerative protocolitis associated with primary cytomegalovirus infection. Arch Intern Med 150:1749–1750, 1990
Falagas ME, Griffiths J, Prekezes J, Worthington M: Cytomegalovirus colitis mimicking colon carcinoma in an HIV-negative patient with chronic renal failure. Am J Gastroenterol 91:168–169, 1996
Coll PP, Pacala J, Hamilton CW: Cytomegalovirus colitis in an older woman, successfully treated with ganciclovir. J Fam Prac 34:772–775, 1992
Machens A, Bloechle C, Achilles EG, Bause WH, Izbicki JR: Toxic megacolon caused by cytome galovirus colitis in a multiply injured patient. J Trauma 40:644–646, 1996
Ho M: Epidemiology of cytomegalovirus infection. Rev Infect Dis 12:S701–S710, 1990
Rosen P, Armstrong D, Rice N: Gastrointestinal cytome galovirus infection. Arch Intern Med 132:274–276, 1973
Levine R, Warnker N, Johnson C: Cytomegalovirus inclusion disease in the gastrointestinal tract of adults. Ann Surg 159:37–48, 1964
Dieterich DT, Rahmin M, Johnson C: Cytomegalovirus colitis in AIDS: Prese ntation in 44 patients and a review of the literature. J AIDS 4:S29–S35, 1991
Sutheriand DE, Chan FY, Foucar K, Simmons RL, Howard RJ, Najarian JS: The bleeding cecal ulcer in transplant patients. Surgery 86:386–398, 1979
Cho SR, Tisnado J, Liu CL, Beachley MC, Shaw CI, Kipreos BE, Schneider V: Bleeding cytome galovirus ulcers of the colon: barium enema and angiography. AJR 136:1213–1215, 1981
Rene E, Marche C, Chevalier T, Rouzious C, Regnier B, Saimot AG, Negesse Y, Matherson S, Leport C, Wolff B, Moriniere B, Katlama C, Godeberge B, Vittecoq B, Bricaire F, Brun-Vesinet C. Cytomegalovirus colitis in patients with acquired immunodeficiency syndrome. Dig Dis Sci 33:741–750, 1988
Teixidor HS, Honig CL, Norsoph E: Cytomegalovirus infection of the alimentary canal: Radiologicfindings with pathologic correlation. Radiology 163:317–323, 1987
Chau TN, Lau LK, Lee KC, Kwok ML, Lai ST, Yuen H: Association of self-limited cytome galovirus colitis and shigellosis in an immunocompetent patient. Eur J Gastroenterol Hepatol 8:819–822, 1996
Peters BS, Becks EJ, Anderson S, Coleman D, Coker R, Main J, Migdal C, Harris JR, Pinching AJ: Cytomegalovirus infection in AIDS. Patterns of diseases, response to therapy and trends in survival. J Infect 23:129–137, 1991
Drew WL: Cytomegalovirus infection in patients with AIDS. J Infect Dis 158:449–456, 1988
Griffiths PD, Grundy JE: Molecular biology and immunology of cytomegalovirus. Biochemistry 241:313–324, 1987
Crowe S, Mills J: Infections of the immune system. In Basic and Clinical Immunology, 7th ed. DP Sitetes, AI Terr (eds). Prentice-Hall, Englewood Childs, New Jersey.
Frank TS, Himebaugh KS, Wilson MD: Granulomatous endome tritis associated with histologically occult cytome galovirus in a healthy patient. Am J Surg Pathol 16:716–720, 1992
Lobdell DH: `Ring' granulomas in cytomegalovirus hepatitis. Arch Pathol Lab Med 111:881–882, 1987
Grundy JE: Virologic and pathogenetic aspects of cytomegalovirus infection. Rev Infect Dis 12( suppl 7):S711–S719, 1990
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Ng, FH., Chau, TN., Cheung, TC. et al. Cytomegalovirus Colitis in Individuals Without Apparent Cause of Immunodeficiency. Dig Dis Sci 44, 945–952 (1999). https://doi.org/10.1023/A:1026604529393
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DOI: https://doi.org/10.1023/A:1026604529393