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Multiple Biochemical Activities of NM23/NDP Kinase in Gene Regulation

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Abstract

NM23/NDPk proteins play critical roles in cancer and development; however, our understanding of the underlying biochemical mechanisms is still limited. This large family of highly conserved proteins are known to participate in many events related to DNA metabolism, including nucleotide binding and nucleoside triphosphate synthesis, DNA binding and transcription, and cleavage of DNA strands via covalent protein–DNA complexes. The chemistry of the DNA-cleavage reaction of NM23-H2/NDPk is characteristic of DNA repair enzymes. Both the DNA cleavage and the NDPk reactions are conserved between E. coli and the human enzymes, and several conserved amino acid side chains involved in catalysis are shared by these reactions. It is proposed here that NM23/NDP kinases are important regulators of gene expression during development and cancer via previously unrecognized roles in DNA repair and recombination, and via previously unrecognized pathways and mechanisms of genetic control.

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References

  • Aebi, S., Kurdi-Haidar, B., Gordon, R., Cenni, B., Zheng, H., Fink, D., Christen, R. D., Boland, C. R., Koi, M., Fishel, R., and Howell, S. B. (1996). Cancer Res. 56, 3087-3090.

    PubMed  Google Scholar 

  • Agou, F., Raveh, S., Mesnildrey, S., and Veron, M. (1999). J. Biol. Chem. 274, 19630-19638.

    PubMed  Google Scholar 

  • Arnaud-Dabernat, S., Daniel, J-Y., Landry, M., Peuchant, K. M.,Boutbon, P. M., Le Floch, R., Larou, M., submitted.

  • Berberich, S. J., and Postel, E. H. (1995). Oncogene 10, 2343-2347.

    PubMed  Google Scholar 

  • Bernard, M. A., Ray, N. B., Olcott, M. C., Hendricks, S. P., and Mathews, C. K. (2000). J. Bioenerg. Biomembr. 32, 259-267.

    PubMed  Google Scholar 

  • Boles, C., Hogan, M. (1987). Biochemistry 26, 367-376.

    PubMed  Google Scholar 

  • Bruner, S. D., Norman, D. P. G., and Verdine, G. L. (2000). Nature 403, 859-866.

    PubMed  Google Scholar 

  • Cho, S. J., Lee, N. S., Jung, Y. S., Lee, H., Lee, K. J., Kim, E., and Chae, S. K. (2001). Biochem. Biophys. Res. Commun. 289, 738-743.

    PubMed  Google Scholar 

  • Cooney, M., Czernuszewicz, G., Postel, E., Flint, S. J., and Hogan, M. E. (1988). Science 242, 456-459.

    Google Scholar 

  • Cunningham, R. P. (1997). Mutat. Res. 383, 189-196.

    PubMed  Google Scholar 

  • Dabernat, S., Bourbon, P.-M., Larou, M., Masse, K., Landry, M., Dierich, A., Lemeur, M., and Daniel, J.-Y. (1999). The Third International Congress of the Genetics, Biochemistry and Physiology of nm23/Nucleoside Diphosphate Kinase, T2.

  • David, S. S., and Williams, S. D. (1998). Chem. Rev. 98, 1221-1262.

    PubMed  Google Scholar 

  • Dianov, G. L., Souza-Pinto, N., Nyaga, S. G., Thybo, T., Stevnsner, T., and Bohr, V. A. (2001). Prog. Nucleic Acid Res. Mol. Biol. 68, 285-297.

    PubMed  Google Scholar 

  • Dodson, M. L., Michaels, M. L., and Lloyd, R. S. (1994). J. Biol. Chem. 269, 32709-32712.

    PubMed  Google Scholar 

  • Dogliotti, E., Fortini, P., Pascucci, B., and Parlanti, E. (2001). Prog. Nucleic Acid Res. Mol. Biol. 68, 3-27.

    PubMed  Google Scholar 

  • Ferguson, A. W., Flatow, U., MacDonald, N. J., Larminat, F., Bohr, V. A., and Steeg, P. S. (1996). Cancer Res. 56, 2931-2935.

    PubMed  Google Scholar 

  • Hailat, N., Keim, D. R., Melhem, R. F., Zhu, X., Eckerskorn, C., Brodeur, G. M., Reynolds, C. P., Seeger, R. C., Lottspeich, F., Strahler, J. R., and Hanash, S. M. (1991). J. Clin. Invest. 88, 341-345.

    PubMed  Google Scholar 

  • Hartsough, M., and Steeg, P. S. (2000). J. Bioenerg. Biomembr. 32, 301.

    PubMed  Google Scholar 

  • Hildebrandt, M., Lacombe, M.-L., Mesnildrey, S., and Véron, M. (1995). Nucleic Acids Res. 23, 3858-3864.

    PubMed  Google Scholar 

  • House, P., Volk, D., Thiviyanathan, V., Manuel, R., Luxon, B., Gorenstein, D., and Lloyd, R. S. (2001). Prog. Nucleic Acid Res. Mol. Biol. 68, 349-364.

    PubMed  Google Scholar 

  • Janin, J., Dumas, C., Morera, S., Xu, Y., Meyer, P., Chiadmi, M., and Cherfils, J. (2000). J. Bioenerg. Biomembr. 32, 215-225.

    PubMed  Google Scholar 

  • Ji, L., Arcinas, M., and Boxer, L. M. (1995). J. Biol. Chem. 270, 13392-13398.

    PubMed  Google Scholar 

  • Jiricny, J. (1996). Cancer Surv. 28, 47-68.

    PubMed  Google Scholar 

  • Kolodner, R. D. (1995). Trends Biol. Sci. 20, 397-401.

    Google Scholar 

  • Krokan, H. E., Nilsen, H., Skorpen, F., Otterlei, M., and Slupphaug, G. (2000). FEBS Lett. 476, 73-77.

    PubMed  Google Scholar 

  • Kunz, B. A., Kohalmi, S., Kunkel, T. A., Mathews, C. K., McIntosh, E. M., and Reidy, J. A. (1994). Mutat. Res. 318, 1-64.

    PubMed  Google Scholar 

  • Lacombe, M.-L., Milon, L., Munier, A., Mehus, J. G., and Lambeth, D. O. (2000). J. Bioenerg. Biomembr. 32, 247-258.

    PubMed  Google Scholar 

  • Lascu, I. (2000). J. Bioenerg. Biomembr. 32, 213-214.

    PubMed  Google Scholar 

  • Lascu, I., Giartosio, A., Ransac, S., and Erent, M. (2000). J. Bioenerg. Biomembr. 32, 227-236.

    PubMed  Google Scholar 

  • Leadon, S. A. (1999). “Transcription-coupled repair of DNA damage: Unanticipated players, unexpected complexities” Am. J. Hum. Genet. 64(5), 1259-1263.

    PubMed  Google Scholar 

  • Le Page, F., Randrianarison, V., Marot, D., Cabannes, J., Perricaudet, M., Feunteun, J., and Sarasin, A. (2000). Cancer Res. 60, 5548-5552.

    PubMed  Google Scholar 

  • Levit, M. N., Abramczyk, B. M., Stock, J. B., and Postel, E. H. (2002). J. Biol. Chem. 277, 5163-5167.

    PubMed  Google Scholar 

  • Lindahl, T., and Wood, R. D. (1999). Science 286, 1897-1905.

    PubMed  Google Scholar 

  • Lloyd, R. S., and Linn, S. (1993). Nucleases, 2nd edn., Cold Spring Harbor Laboratory Press, New York, pp. 263-316.

    Google Scholar 

  • Loeb, L. A. (1998). Adv. Cancer Res. 72, 25-56.

    PubMed  Google Scholar 

  • Lombardi, D., Lacombe, M. L., and Paggi, M. G. (2000). J. Cell. Physiol. 182, 144-149.

    PubMed  Google Scholar 

  • Lu, Q., Park, H., Egger, L. A., and Inouye, M. (1996). J. Biol. Chem. 271, 32886-32893.

    PubMed  Google Scholar 

  • Lu, Q., Zhang, X., Almaula, N., Mathews, C., and Inouye, M. (1995). J. Mol. Biol. 254, 337-341.

    PubMed  Google Scholar 

  • Ma, D., Xing, Z., Liu, B., Pedigo, N. G., Zimmer, S. G., Bai, Z., Postel, E. H., and Kaetzel, D. M. (2002). J. Biol. Chem. 277, 1560-1567.

    PubMed  Google Scholar 

  • MacLachlan, T. K., Somasundaram, K., Sgagias, M., Shifman, Y., Muschel, R. J., Cowan, K. H., and El-Deiry, W. S. (2000). J. Biol. Che. 275, 2777-2785.

    Google Scholar 

  • Malins, D. C., Polissar, N. L., and Gunselman, S. J. (1996). Proc. Natl. Acad. Sci. U.S.A. 93, 2557-2563.

    PubMed  Google Scholar 

  • Malins, D. C., Polissar, N. L., Schaefer, S., Su, Y., and Vinson, M. (1998). Proc. Natl. Acad. Sci. U.S.A. 95, 7637-7642.

    PubMed  Google Scholar 

  • McCullough, A. K., Dodson, M. L., and Lloyd, R. S. (1999). Annu. Rev. Biochem. 68, 255-285.

    PubMed  Google Scholar 

  • Michelotti, E. F., Tomonaga, T., Krutzsch, H., and Levens, D. (1995). J. Biol. Chem. 270, 9494-9499.

    PubMed  Google Scholar 

  • Miller, J. H., Funchain, P., Clendenin, W., Huang, T., Nguyen, A., Wolff, E., Yeung, A., Chiang, J.-H., Garibyan, L., Slupska, M. M., and Yang, H. (2002). Genetics. 162, 5-13.

    PubMed  Google Scholar 

  • Milon, L., Meyer, P., Chiadmi, M., Munier, A., Johansson, M., Karlsson, A., Lascu, I., Capeau, J., Janin, J. and Lacombe, M. L. (2000). J. Biol. Chem. 275, 14264-14272.

    PubMed  Google Scholar 

  • Modrich, P. (1991). Annu. Rev. Genet. 25, 229-253.

    PubMed  Google Scholar 

  • Modrich, P., and Lahue, R. (1996). Annu. Rev. Biochem. 65, 101-133.

    PubMed  Google Scholar 

  • Mol, C. D., Parikh, S. S., Putnam, C. D., Lo, T. P., and Tainer, J. A. (1999). Annu. Rev. Biophys. Biomol. Struct. 28, 101-128.

    PubMed  Google Scholar 

  • Moréa, S., Lacombe, M. L., Xu, Y., LeBras, G., and Janin, J. (1995). Structure 3, 1307-1314.

    PubMed  Google Scholar 

  • Munier, A., Serres, C., Kann, M. L., Capeau, J., Fouquet, J. P., and Lacombe, M. L. (2001). The Fourth International Congress of the Genetics, Biochemistry and Physiology of NDP Kinase/NM23/AWD, T3, Tokyo, Japan.

  • Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., and Honjo, T. (2000). Cell 102, 553-563.

    PubMed  Google Scholar 

  • Nash, H. M., Lu, R., Lane, W. S., and Verdine, G. L. (1997). Chem. Biol. 4, 693-702.

    PubMed  Google Scholar 

  • Pongubala, J. M., and Atchison, M. L. (1997). Proc. Natl. Acad. Sci. U.S.A. 94, 127-132.

    PubMed  Google Scholar 

  • Postel, E. H. (1998). Int. J. Biochem. Cell. Biol. 30, 1291-1295.

    PubMed  Google Scholar 

  • Postel, E. H. (1999). J. Biol. Chem. 274, 22821-22829.

    PubMed  Google Scholar 

  • Postel, E. H. Abramczyk, B. A., Gursky, S. K., and Xu, Y. (2002). Biochemistry 41, 6330-6337.

    PubMed  Google Scholar 

  • Postel, E. H., Abramczyk, B. M., Levit, M. N., and Kyin, S. (2000a). Proc. Natl. Acad. Sci. U.S.A. 97, 14194-14199.

    PubMed  Google Scholar 

  • Postel, E. H., Berberich, S. J., Flint, S. J., and Ferrone, C. A. (1993). Science 261, 478-480.

    PubMed  Google Scholar 

  • Postel, E. H., Berberich, S. J., Rooney, J. W., and Kaetzel, D. M. (2000b). J. Bioenerg. Biomembr. 32, 277-284.

    PubMed  Google Scholar 

  • Postel, E. H., and Ferrone, C. A. (1994). J. Biol. Chem. 269, 8627-8630.

    PubMed  Google Scholar 

  • Postel, E. H., Mango, S. E., and Flint, S. J. (1989). Mol. Cell. Biol. 9, 5123-5133.

    PubMed  Google Scholar 

  • Postel, E. H., Weiss, V. H., Beneken, J., and Kirtane, A. (1996). Proc Natl. Acad. Sci. U.S.A. 93, 6892-6897.

    PubMed  Google Scholar 

  • Sager, R. (1997). Proc. Natl. Acad. Sci. U.S.A. 94, 952-955.

    PubMed  Google Scholar 

  • Sanchez-Cespedes, M., Parrella, P., Nomoto, S., Cohen, D., Xiao, Y., Esteller, M., Jeronimo, C., Jordan, R. C., Nicol, T., Koch, W. M., Schoenberg, M., Mazzarelli, P., Fazio, V. M., and Sidransky, D. (2001). Cancer Res. 61, 7015-7019.

    PubMed  Google Scholar 

  • Siddiqui-Jain, A., Grand, C. L., Bearss, D. J., and Hurley, L. H. (2003). Proc. Natl. Acad. Sci. 99, 11593-11598.

    Google Scholar 

  • Simonsson, T., Pribylova, M., and Vorlickova, M. (2000). Biochem. Biophys. Res. Commun. 278, 158-166.

    PubMed  Google Scholar 

  • Singh, Y., et al., personal communication.

  • Steeg, P. S., Bevilacqua, G., Kopper, L., Thorgeirsson, U. R., Talmadge, J. E., Liotta, L. A., and Sobel, M. E. (1998). J. Natl. Cancer Inst. 80, 200-205.

    Google Scholar 

  • Venturelli, D., Martinez, R., Melotti, P., Casella, I., Peschle, C., Cucco, C., Spampinato, G., Darzynkiewicz, Z., and Calabretta, B. (1995). Proc. Natl. Acad. Sci. U.S.A. 92, 7435-7439.

    PubMed  Google Scholar 

  • Wagner, P. D., Steeg, P. S., and Vu, N. D. (1997). Proc. Natl. Acad. Sci. U.S.A. 94, 9000-9005.

    PubMed  Google Scholar 

  • Webb, P. A., Perisic, O., Mendola, C. E., Backer, J. M., and Williams, R. L. (1995). J. Mol. Biol. 251, 574-587.

    PubMed  Google Scholar 

  • Zdraveski, Z. Z., Mello, J. A., Farinelli, C. K., Essigmann, J. M., and Marinus, M. G. (2002). J. Biol. Chem. 277, 1255-1260.

    PubMed  Google Scholar 

  • Zhang, L., Zhou, W., Velculescu, V. E., Kern, S. E., Hruban, R. H., Hamilton, S. R., Vogelstein, B., and Kinzler, K. W. (1997). Science 276, 1268-1272.

    PubMed  Google Scholar 

  • Zou, X., and Perlmutter, R. (2001). The Fourth International Congress of the Genetics, Biochemistry and Physiology of NDP Kinase/NM23/AWD Tokyo, Japan.

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  1. Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08546-5414

    Edith H. Postel

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Postel, E.H. Multiple Biochemical Activities of NM23/NDP Kinase in Gene Regulation. J Bioenerg Biomembr 35, 31–40 (2003). https://doi.org/10.1023/A:1023485505621

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