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Mesenchymal stem cells combined with biphasic calcium phosphate ceramics promote bone regeneration

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Abstract

The reconstruction and repair of large bone defects, resulting from trauma, cancer or metabolic disorders, is a major clinical challenge in orthopaedics. Clinically available biological and synthetic grafts have clear limitations that necessitate the development of new graft materials and/or strategies. Human mesenchymal stem cells (MSCs), obtained from the adult bone marrow, are multipotent cells capable of differentiating into various mesenchymal tissues. Of particular interest is the ability of these cells to differentiate into osteoblasts, or bone-forming cells. At Osiris, we have extensively characterized MSCs and have demonstrated MSCs can induce bone repair when implanted in vivo in combination with a biphasic calcium phosphate, specifically hydroxyapatite/tricalcium phosphate. This article reviews previous and current studies utilizing mesenchymal stem cells and biphasic calcium phosphates in bone repair.

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References

  1. M. F. Pittenger, A. M. Mackay, S. C. Beck, R. K. Jaiswal, R. Douglas, J. Mosca, M. A. Moorman, D. W. Simonetti, S. Craig and D. R. Marshak, Science 284 (1999) 143.

    Google Scholar 

  2. A. I. Caplan, D. J. Fink, T. Goto, A. E. Linton, R. G. Young, S. Wakitani, V. Goldberg and S. E. Haynesworth, in “The Anterior Cruciate Ligament: Current and Future Concepts” (Raven Press, New York, 1993) p. 405.

    Google Scholar 

  3. N. Jaiswal, S. E. Haynesworth, A. I. Caplan and S. P. Bruder, J. Cell. Biochem. 64 (1997) 295.

    Google Scholar 

  4. A. Friedenstein, R. Chailakhyan and U. V. Gerasimov, Cell Tissue Kinet. 20 (1987) 263.

    Google Scholar 

  5. D. P. Lennon, S. E. Haynesworth, S. P. Bruder, N. Jaiswal and A. I. Caplan, In Vitro Cell. Dev. Biol. Animal 32 (1996) 602.

    Google Scholar 

  6. J. N. Beresford, Clin. Orthop. 240 (1989) 270.

    Google Scholar 

  7. S. Haynesworth, M. Baber and A. Caplan, J. Cell. Physiol. 138 (1992) 8.

    Google Scholar 

  8. S. Kadiyala, R. G. Young, M. A. Thiede and S. P. Bruder, Cell Transplan. 6 (1997) 125.

    Google Scholar 

  9. M. J. Yaszemski, R. G. Payne, W. C. Hayes, R. Langer and A. G. Mikos, Biomaterials 17 (1996) 175.

    Google Scholar 

  10. A. Gazdag, J. Lane, D. Glaser and R. Forster, J. Am. Acad. Orthop. Surg. 3 (1995) 1.

    Google Scholar 

  11. X. Li, S. Stevenson, L. Klein, D. Davy, J. Shaffer and V. Goldberg, Acta Anat. Basel 140 (1991) 236.

    Google Scholar 

  12. D. Ehrler and A. Vaccaro, Clin. Orthop. 371 (2000) 38.

    Google Scholar 

  13. W. Head, T. Malinin, T. Mallory and R. Emerson, Orthop. Clin. North Am. 29 (1998) 307.

    Google Scholar 

  14. A. Aho, T. Ekfors, P. Dean, H. Aro, A. Ahonen and V. Nikkanen, Clin. Orthop. 307 (1994) 200.

    Google Scholar 

  15. D. Garbuz, B. Masri and A. Czitrom, Orthop. Clin. North Am. 29 (1998) 199.

    Google Scholar 

  16. L. L. Hench, J. Am. Ceram. Soc. 74 (1991) 1487.

    Google Scholar 

  17. E. C. Shors, Orthop. Clin. North Am. 30 (1999) 599.

    Google Scholar 

  18. R. Z. Legeros, Adv. Dental Res. 2 (1988) 164.

    Google Scholar 

  19. P. Patka, G. Den Otter, K. De Groot and A. Driessen, Neth. J. Surg. 37 (1985) 38.

    Google Scholar 

  20. G. Daculsi, N. Passuti, S. Martin, C. Deudon, R. Z. Legeros and S. Raher, J. Biomed. Mater. Res. 24 (1990) 379.

    Google Scholar 

  21. M. Marcacci, E. Kon, S. Zaffagnini, R. Giardino, M. Rocca, A. Corsi, A. Benvenuti, P. Bianco, R. Quarto, I. Martin, A. Muraglia and R. Cancedda, Calcif. Tissue. Int. 64 (1999) 83.

    Google Scholar 

  22. K. Johnson, K. Frierson, T. Keller, C. Cook, R. Scheinberg, J. Zerwekh, L. Meyers and M. Sciadini, J. Orthop. Res. 14 (1996) 351.

    Google Scholar 

  23. C. Friedman, P. Costantino, C. Synderman, L. Chow and S. Takagi, Arch. Facial Plast. Surg. 2 (2000) 124.

    Google Scholar 

  24. O. Gauthier, J. M. Bouler, E. Aguado, P. Pilet and G. Daculsi, Biometerials 19 (1998) 133.

    Google Scholar 

  25. E. J. G. Schepers and P. Ducheyne, J. Oral Rehab. 24 (1997) 171.

    Google Scholar 

  26. Y. Matsusue, T. Kotake, Y. Nakagawa and T. Nakamura, Arthroscopy 17 (2001) 653.

    Google Scholar 

  27. D. Buser, B. Hoffmann, J. Bernard, A. Lussi, D. Mettler and R. Schenk, Clin. Oral. Implants Res. 9 (1998) 137.

    Google Scholar 

  28. K. Hamson, J. Toth, J. Stiehl and K. Lynch, Calcif. Tissue Int. 57 (1995) 64.

    Google Scholar 

  29. H. Ohgushi, Y. Dohi, T. Yoshikawa, S. Tamai, S. Tabata, K. Okunaga and T. Shibuya, J. Biomed. Mater. Res. 32 (1996) 341.

    Google Scholar 

  30. J. Toquet, R. Rohanizadeh, J. Guicheux, S. Couillaud, N. Passuti, G. Daculsi and D. Heymann, ibid. 44 (1999) 98.

    Google Scholar 

  31. T. Livingston, P. Ducheyne and J. Garino, ibid. (2002) in press.

  32. S. Haynesworth, J. Goshima, V. Goldberg and A. Caplan, Bone 13 (1992) 81.

    Google Scholar 

  33. T. A. Einhorn, J. M. Lane, A. H. Burstein, C. R. Kopman and V. J. Vigorita, J. Bone Joint Surg. Am. 66-A (1984) 274.

    Google Scholar 

  34. M. Nottebaert, J. M. Lane, A. Juhn, A. Burnstein, R. Schneider, C. Klein, R. S. Sinn, C. Dowling, C. Cornell and M. Catsimpoolas, J. Orthop. Res. 7 (1989) 157.

    Google Scholar 

  35. S. Kadiyala, N. Jaiswal and S. P. Bruder, Tiss. Eng. 3 (1997) 173.

    Google Scholar 

  36. S. P. Bruder, A. A. Kurth, M. Shea, W. C. Hayes, N. Jaiswal and S. Kadiyala, J. Orthop. Res. 16 (1998) 155.

    Google Scholar 

  37. S. P. Bruder, K. H. Kraus, V. M. Goldberg and S. Kadiyala, J. Bone. Joint Surg. 80-A (1998) 985.

    Google Scholar 

  38. G. Daculsi, Biomaterials 19 (1998) 1473.

    Google Scholar 

  39. T. L. Livingston, G. Dalcusi, M. Elkalay and S. Kadiyala, Am. Soc. Artificial Internal Organs J. 46 (2000) 238.

    Google Scholar 

  40. K. Mcintosh and A. Bartholomew, Graft 3 (2000) 324.

    Google Scholar 

  41. S. Devine, S. Peter, B. J. Martin, F. Barry and K. Mcintosh, Cancer J. 7 (2001) S76.

    Google Scholar 

  42. W. E. Braun, Am. J. Med. Sci. 313 (1997) 279.

    Google Scholar 

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Authors and Affiliations

  1. Osiris Therapeutics, Inc., 2001 Aliceanna Street, Baltimore, MD, 21231, USA

    T. L. Livingston, S. Gordon, M. Archambault, S. Kadiyala, K. McIntosh, A. Smith & S. J. Peter

Authors
  1. T. L. Livingston
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  2. S. Gordon
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  3. M. Archambault
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  4. S. Kadiyala
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  5. K. McIntosh
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  6. A. Smith
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  7. S. J. Peter
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Correspondence to M. Archambault.

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Livingston, T.L., Gordon, S., Archambault, M. et al. Mesenchymal stem cells combined with biphasic calcium phosphate ceramics promote bone regeneration. Journal of Materials Science: Materials in Medicine 14, 211–218 (2003). https://doi.org/10.1023/A:1022824505404

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