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The Nitric Oxide-Endothelin-1 Connection

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Abstract

Nitric oxide (NO) and endothelin-1 (ET-1) are endothelium-derived mediators that play important roles in vascular homeostasis. This review is focused on the role and reciprocal interactions between NO and ET-1 in health and diseases associated with endothelium dysfunction. We will also discuss the clinical significance of NO donors and drugs that antagonize ET receptors.

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  1. Department of Integrative Biology and Pharmacology, University of Texas-Houston, USA

    David Alonso & Marek W. Radomski

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Alonso, D., Radomski, M.W. The Nitric Oxide-Endothelin-1 Connection. Heart Fail Rev 8, 107–115 (2003). https://doi.org/10.1023/A:1022155206928

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