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Bone response to surface modified titanium implants – studies on the tissue response after 1 year to machined and electropolished implants with different oxide thicknesses

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Abstract

The bone formation around titanium implants with varied surface properties was investigated after 1 year in rabbits. Machined and electropolished samples with and without thick, anodically formed surface oxides were prepared, surface characterized and inserted in the cortical bone of rabbits. Scanning electron microscopy, scanning Auger electron spectroscopy and atomic force microscopy revealed marked differences in oxide thickness, surface topography and roughness, but no significant differences in surface chemical composition between the different groups of implants. Light microscopic morphology and morphometry showed that all implants were in contact with bone and had a large proportion of bone within the threads. There were no significant differences between the differently prepared implant groups. Our study shows that a high degree of bone contact and bone formation is achieved after 1 year with titanium implants which are modified with respect to oxide thickness and surface topography. There is no indication that a reduction of surface roughness, which in the initial phase decreases the rate of bone formation, had any influence on the amount of bone after 1 year in rabbit cortical bone.

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References

  1. J. C. KELLER, W. M. J. DOUGHERTY, G. R. GROTENDORST and P. J. WIGHTMAN, J. Adhesion 28 (1989) 115.

    Google Scholar 

  2. J. C. KELLER, R. A. DRAUGHN, J. P. WIGHTMAN, W. J. DOUGHERTY and S. D. MELETIOU, Int. J. Oral Maxillofac. 5 (1990) 360.

    Google Scholar 

  3. M. C. SUNNY and P. C. SHARMA, J. Biomed. Mater. Res. 24 (1990) 455.

    Google Scholar 

  4. K. T. BOWERS, J. C. KELLER, B. A. RANDOLPH, D. G. WICK and C. M. MICHAELS, Int. J. Oral Maxillofacial Impl. 7 (1992) 302.

    Google Scholar 

  5. D. R. COOLEY, A. F. VAN DELLEN, J. O. BURGESS and A. S. WINDELER, J. Prosth. Dent. 67 (1992) 93.

    Google Scholar 

  6. P. DUCHEYNE, S. RADIN and L. KING, J. Biomed. Mater. Res. 27 (1993) 25.

    Google Scholar 

  7. J. HAMBLETON, Z. SCHWARTZ, A. KHARE, S. W. WINDELER, M. LUNA, B. P. BROOKS, D. D. DEAN and B. D. BOYAN, J. Orthop. Res. 12 (1994) 542.

    Google Scholar 

  8. J. Y. MARTIN, Z. SCHWARTZ, T. W. HUMMERT, D. M. SCHRAUB, J. SIMPSON, J. J. LANKFORD, D. D. DEAN, D. L. COCHRAN and B. D. BOYAN, J. Biomed. Mater. Res. 29 (1995) 389.

    Google Scholar 

  9. Z. SCHWARTZ, J. Y. MARTIN, D. D. DEAN, J. SIMPSON, D. L. COCHRAN and B. D. BOYAN, ibid. 30(2) (1996) 145.

    Google Scholar 

  10. C. LARSSON, P. THOMSEN, B. O. ARONSSON, M. RODAHL, J. LAUSMAA, B. KASEMO and L. E. ERICSON, Biomaterials 15 (1994) 1062.

    Google Scholar 

  11. B. KASEMO and J. LAUSMAA, Swed. Dent. J. Suppl. 28 (1985) 19.

    Google Scholar 

  12. T. ALBREKTSSON, P.-I. BRÅNEMARK, H.-A. HANSSON, B. KASEMO, K. LARSSON, I. LUNDSTRÖM, D. MCQUEEN and R. SKALAK, Ann. Biomed. Engng 11 (1983) 1.

    Google Scholar 

  13. R. HAZAN, R. BRENER and U. ORON, Biomaterials 14 (1993) 570.

    Google Scholar 

  14. J. C. KELLER, C. M. STANFORD, J. P. WIGHTMAN, R. A. DRAUGN and R. ZAHARIAS, J. Biomed. Mater. Res. 28 (1994) 939.

    Google Scholar 

  15. K. M. SWART, J. C. KELLER, J. P. WIGHTMAN, R. A. DRAUGN, C. M. STANFORD and C. M. MICHAELS, J. Oral Implant. 18 (1992) 130.

    Google Scholar 

  16. B. CHEHROUDI, T. R. L. GOULD and D. M. BRUNETTE, J. Biomed. Mater. Res. 23 (1989) 1067.

    Google Scholar 

  17. Idem, ibid. 24 (1990) 1202.

    Google Scholar 

  18. D. BUSER, R. K. SEHENK, S. STEINEMANN, J. P. FIORELLINI, C. H. FOX and H. STITCH, ibid. 25 (1991) 889.

    Google Scholar 

  19. M. KÖNÖNEN, M. HORMIA, J. KIVILAHTI, J. HAUTANIEMI and I. THESLEFF, J. Biomed. Mater. Sci. 26 (1992) 1325.

    Google Scholar 

  20. M. THERIN, A. MEUNIER and P. CHRISTEL, J. Mater. Sci. Mater. Med. 2 (1991) 1.

    Google Scholar 

  21. J. L. RICCI, J. M. SPIVAK, N. C. BLUMENTHAL and H. ALEXANDER, in “The bone-biomaterial interface”, edited by J. E. Davies (Toronto University Press, Toronto, 1991, pp. 334–49.

    Google Scholar 

  22. J.-E. SUNDGREN, P. BODÖ and I. LUNDSTRÖM, J. Coll. Interface Sci. 110 (1986) 9.

    Google Scholar 

  23. J. LAUSMAA, J. Electron Spectrosc. Rel. Phenom. 81 (1996) 343.

    Google Scholar 

  24. C. LARSSON, P. THOMSEN, B.-O. ARONSSON, M. RODAHL, J. LAUSMAA, B. KASEMO and L.E. ERICSON, Biomaterials 17 (1996) 605.

    Google Scholar 

  25. J. LAUSMAA, B. KASEMO, H. MATTSSON and H. ODELIUS, Appl. Surface Sci. 45 (1990) 189.

    Google Scholar 

  26. J. LAUSMAA, B. KASEMO, U. ROLANDER, L. M. BJURSTEN, L. E. ERICSON, L. ROSANDER and P. THOMSEN, in “Surface Characterization of Biomaterials”, edited by B. D. Ratner (Elsevier, New York, 1988) pp. 161–74.

    Google Scholar 

  27. J. LAUSMAA, “Surface oxides on titanium: Preparation, characterization and biomaterial properties”, PhD Thesis, University of Gothenburg (1991).

  28. D. LANDOLT, Electrochim. Acta 32 (1987) 1.

    Google Scholar 

  29. S. D. ROSS, “Anodic oxidation”, Organic Chemistry, Vol. 32, (Academic Press, New York, 1975).

    Google Scholar 

  30. L. E. DAVIS, N. C. MacDONALD, P. W. PALMBERG, G. E. RIACH and R. E. WEBER, “Handbook of Auger electron spectroscopy”, (Physical Electronics, Eden Prairie, 1978).

    Google Scholar 

  31. D. SARID and V. ELINGS, J. Vac. Sci. Technol. B 9 (1991) 431.

    Google Scholar 

  32. J. E. GRIFFITH, D. A. GRIGG, M. J. VASILE, P. E. RUSSELL and E. A. FITZGERALD, J. Vac. Sci. Technol. A 10 (1992) 674.

    Google Scholar 

  33. K. DONATH and G. A. BREUNER, J. Oral Pathol. 11 (1982) 318.

    Google Scholar 

  34. J. LAUSMAA, B. KASEMO and H. MATTSSON, Appl. Surf. Sci. 44 (1990) 133.

    Google Scholar 

  35. G. D. DAVIS, M. NATAN and K. A. ANDERSON, ibid. 15(1983) 321.

    Google Scholar 

  36. A. M. BARO, N. GARCIA, R. MIRANDA, L. VAZQUES, C. APARICIO, J. OLIVÉ and J. LAUSMAA, Biomaterials 7 (1986) 463.

    Google Scholar 

  37. H. OLIN, B.-O. ARONSSON, B. KASEMO, J. LAUSMMA and M. RODAHL, Ultramicroscopy 42–44 (1992) 567.

    Google Scholar 

  38. M. JOBIN, R. EMCH, F. ZENHAUSERN, S. STEINEMANN and P. DESCOUTS, J. Vac. Sci. Technol. B 9 (1991) 1263.

    Google Scholar 

  39. L. SENNERBY, P. THOMSEN and L. E. ERICSON, Int. J. Oral Maxillofac. Impl. 7 (1992) 62.

    Google Scholar 

  40. Idem, J. Mater. Sci. Mater. Med. 4 (1993) 493.

    Google Scholar 

  41. Idem, ibid. 4 (1993) 240.

    Google Scholar 

  42. A. WENNERBERG, A. EKTESSABI, T. ALBREKTSSON, C. JOHANSSON and B. ANDERSSON, (1996) to be published.

  43. M. QUIRYNEN, C. M. L. BOLLEN, G. WILLEMS and D. VAN STEENBERGHE, Int. J. Oral Maxillofac. Impl. 9 (1994) 71.

    Google Scholar 

  44. A. WENNERBERG, T. ALBREKTSSON,and B. ANDERSSON, ibid. 8 (1993) 622.

    Google Scholar 

  45. N. C. BLUMENTHAL and V. COSMA, J. Biomed. Mater. Res. 23 (1989) 13.

    Google Scholar 

  46. K. E. HEALEY and P. DUCHEYNE, ibid. 26 (1992) 319.

    Google Scholar 

  47. Idem, J. Coll. Interface Sci. 150 (1992) 404.

    Google Scholar 

  48. A. RICH and K. A. HARRIS, J. Cell Sci. 50 (1981) 1.

    Google Scholar 

  49. T. N. SALTHOUSE, J. Biomed. Mater. Res. 18 (1984) 395.

    Google Scholar 

  50. P. VAN DER VALK, A. W. J. VAN PELT, H. J. BUSSCHER, H. P. D. JONG, C. R. H. WILDEVAR and J. ARENOS, ibid. 17 (1983) 807.

    Google Scholar 

  51. D. COCHRAN, J. SIMPSON, H. WEBER and D. BUSER, Int. J. Oral Maxillofac. Impl. 9 (1994) 289.

    Google Scholar 

  52. B. D. BOYAN, T. W. HUMMERT, K. KIESWETTER, D. SCHRAUB, D. D. DEAN and Z. SCHWARTZ, Cells Mater. 5 (1995) 323.

    Google Scholar 

  53. P.-I. BRÅNEMARK, U. BREINE, R. ADELL, B. O. HANSSON, J. LINDSTRÖM and A. OHLSSON, Scand. J. Plast. Reconstr. Surg. 3 (1969) 81.

    Google Scholar 

  54. T. ALBREKTSSON, P.-I. BRÅNEMARK, H.-A. HANSSON and J. LINDSTRÖM, Acta Orthop. Scand. 52 (1981) 155.

    Google Scholar 

  55. T. ALBREKTSSON, CRC Crit. Rev. Biocomp. 1 (1985) 53.

    Google Scholar 

  56. S. G. STEINEMANN, J. EULENBERG, P. A. MAEUSLI and A. SCHROEDER, in “Biological and biomechanical performance of biomaterials”, edited by M. A. P. Christel and A. J. C. Lee (Elsevier, Amsterdam, 1989) pp. 409–14.

    Google Scholar 

  57. G. A. ZARB and T. ALBREKTSSON, J. Periodont. Res. Dent. 11 (1991) 88.

    Google Scholar 

  58. R. BRÅNEMARK, PhD thesis, Göteborg University (1996).

  59. L. SENNERBY, L. E. ERICSON, P. THOMSEN, U. LEKHOLM and P. ÅSTRAND, J. Clin. Oral Impl. Res. 2 (1991) 103.

    Google Scholar 

  60. M. ESPOSITO, P. THOMSEN, J. MÖLNE, C. GRETZER, L. E. ERICSON and U. LEKHOLM, ibid. (1997) in press.

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Authors and Affiliations

  1. Institute of Anatomy and Cell Biology, Goteborg University, Sweden

    C LARSSON

  2. Department of Applied Physics, Chalmers University of Technology, Goteborg, Sweden

    L EMANUELSSON

  3. Department of Materials Technology, Swedish National Testing and Research Institute (SP), Boras, Sweden

    P THOMSEN

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  1. C LARSSON
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  2. L EMANUELSSON
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  3. P THOMSEN
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  4. L. E ERICSON
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  5. B.-O ARONSSON
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  6. B KASEMO
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  7. J LAUSMAA
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LARSSON, C., EMANUELSSON, L., THOMSEN, P. et al. Bone response to surface modified titanium implants – studies on the tissue response after 1 year to machined and electropolished implants with different oxide thicknesses. Journal of Materials Science: Materials in Medicine 8, 721–729 (1997). https://doi.org/10.1023/A:1018548225899

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