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Leukemias and lymphomas: time trends in the UK, 1984–93

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Abstract

Objective: To investigate recent time trends of some selected and common neoplasms of the blood and lymphatic tissues.

Methods: A specialist population-based register of hematological and related neoplasms was set up in parts of the UK in 1984. Secular changes over the first 10 years were investigated using log-linear Poisson modeling. The results are presented in tabular and graphical form.

Results: The analyses of 26,899 cases revealed a decline in incidence of acute myeloid leukaemia (AML), the myeloproliferative disorders (MPD) including chronic myeloid leukaemia (CML) and, in males only, Hodgkin's disease (HD). No secular trends for acute lymphoblastic leukaemia (ALL) were observed at any age. A marked increase in incidence in non-Hodgkin's disease (NHL) and the pre- leukemia group of myeloid dysplasias (MDS) was found.

Conclusions: The rise in MDS and decline in AML and related conditions are most likely to reflect diagnostic changes. Changes in NHL may reflect, in part, a similar phenomena, but an underlying upward trend cannot be excluded. The decline in HD is in one gender only and the significance of this remains to be investigated.

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References

  1. Birch JM, Marsden HB, Swindell R (1980) Incidence of malignant disease in childhood: a 24-year review of the Manchester children's tumour registry data. Br J Cancer 42: 215-223.

    Google Scholar 

  2. Kramer S, Meadows AT, Jarrett P, Evans AE (1983) Incidence of childhood cancer: experience of a decade in a population-based registry. J Natl Cancer Inst 70: 49-55.

    Google Scholar 

  3. van Hoff J, Schymura MJ, McCrea Curnen MG (1988) Trends in the incidence of childhood and adolescent cancer in Connecticut, 1935–1979. Med Paed Oncol 16: 78-87.

    Google Scholar 

  4. Coebergh JW, van der Does-van den Berg A, van Wering ER, et al. (1989) Childhood leukaemia in the Netherlands, 1973–1986: temporary variation of the incidence of acute lymphocytic leukaemia in young children. Br J Cancer 59: 100-105.

    Google Scholar 

  5. Cartwright RA (1992 ) Changes in the descriptive epidemiology of non-Hodgkin's lymphoma in Great Britain. Cancer Res 52(Suppl): 5441-5442.

    Google Scholar 

  6. Devesa SS, Fears T (1992) Non-Hodgkin's lymphoma time trends: United States and international data. Cancer Res 52(Suppl): 5432-5440.

    Google Scholar 

  7. McCredie M, Hoyer A, Coates M, Taylor R (1992). Trends in Cancer Incidence and Mortality in New South Wales 1972–1989. Woolloomooloo, UK: New South Wales Central Cancer Registry.

    Google Scholar 

  8. Miller BA, Ries LAG, Hankey BF, Kosary CL, Edwards BK, eds. (1992) Cancer Statistics Review: 1973–1989. National Cancer Institute (NIH Publication No 92-2789). Bethesda, MD: United States Department of Health and Human Services.

    Google Scholar 

  9. Coleman MP, Esteve J, Damiecki P, Arslan A, Renard H (1993) Trends in Cancer Incidence and Mortality. Lyon: IARC Sci. Pub. No. 121.

  10. Doll R, Fraumeni J, Muir CS (1994) Trends in Cancer Incidence and Mortality, ICRF, Cancer Surveys, 1994; Vols. 19/20. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.

    Google Scholar 

  11. Draper GJ, Kroll ME, Stiller CA Childhood cancer. In: Doll R, Fraumeni JF, Muir CS (1994) Trends in Cancer Incidence and Mortality, ICRF, Cancer Surveys, 1994; Vols. 19/20. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp. 493-517.

    Google Scholar 

  12. Hartge P, Devesa SS, Fraumeni JF (1994) Hodgkin's and non-Hodgkin's lymphomas. In: Doll R, Fraumeni JF, Muir CS. Trends in Cancer Incidence and Mortality, ICRF, Cancer Surveys, 1994; Vols. 19/20. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp. 423-453.

    Google Scholar 

  13. McNally RJQ, Alexander FE, Staines A, Cartwright RA (1997) A comparison of three methods of analysis for Age-Period-Cohort models with application to incidence data on non-Hodgkin's lymphoma. Int J Epidemiol 26: 32-46.

    Google Scholar 

  14. Cartwright RA, Alexander FE, McKinney PA, Ricketts TJ (1990) Leukaemia and Lymphoma: An Atlas of Distribution within Areas of England and Wales 1984–1988. London: Leukaemia Research Fund.

    Google Scholar 

  15. Cartwright RA, McNally RJQ, Thomas J, Rowland D (1997) Leukaemia and Lymphoma: A Monograph of Distribution within Areas of England and Wales 1984–1993. London: Leukaemia Research Fund.

    Google Scholar 

  16. Doll R, Payne P, Waterhouse J, eds. (1966) Cancer Incidence in Five Continents, Vol. I. International Union Against Cancer, Springer Verlag.

  17. Doll R, Muir C, Waterhouse J, eds. (1990) Cancer Incidence in Five Continents, Vol. II. International Union Against Cancer, Springer Verlag.

  18. Waterhouse J, Muir C, Correa P, Powell J, eds. (1997) Cancer Incidence in Five Continents, Vol. III. IARC Sci. Pub. No. 15. Lyon: International Agency for Research on Cancer.

    Google Scholar 

  19. Waterhouse J, Muir C, Shanmugaratnam K, Powell J, eds. (1982) Cancer Incidence in Five Continents, Vol. IV. IARC Sci. Pub. No. 42. Lyon: International Agency for Research on Cancer.

    Google Scholar 

  20. Muir CS, Waterhouse J, Mack T, Powell J, Whelan S, eds. (1987) Cancer Incidence in Five Continents, Vol. V. IARC Sci. Pub. No. 88. Lyon: International Agency for Research on Cancer.

    Google Scholar 

  21. Parkin DM, Muir CS, Whelan SL, Gao YT, Ferlay J, Powell J, eds. (1992) Cancer Incidence in Five Continents, Vol. VI. IARC Sci. Pub. No. 120. Lyon: International Agency for Research on Cancer.

    Google Scholar 

  22. Bennett JM, Catovsky D, Daniel MT (1982) The Franco American British (FAB) co-operative group proposals for the classification of the myelodysplastic syndrome. Br J Haematol 51: 189-199.

    Google Scholar 

  23. Blair V, Birch JM (1994) Patterns and temporal trends in the incidence of malignant disease in children: I: Leukaemia and lymphoma. Eur J Cancer 30A: 1490-1498.

    Google Scholar 

  24. Cartwright RA, McNally RJQ (1994a) Epidemiology of non-Hodgkin's lymphoma. Cambridge Medical Reviews. Haematol Oncol 3: 1-34.

    Google Scholar 

  25. Cartwright RA, McNally RJQ, Staines A (1994b) The increasing incidence of non-Hodgkin's lymphoma (NHL): The possible role of sunlight? Leukaemia Lymphoma 14: 387-394.

    Google Scholar 

  26. International Agency for Research on Cancer (1996) Human Immunodeficiency Viruses and Human T-cell Lymphotropic Viruses. Monogr Eval Carcinog Risks Humans, Vol. 67. Lyon: IARC.

    Google Scholar 

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Authors and Affiliations

  1. Leukaemia Research Fund Centre for Clinical Epidemiology, University of Leeds, 17 Springfield Mount, Leeds, UK

    Richard J.Q. McNally

  2. Leukaemia Research Fund Centre for Clinical Epidemiology, University of Leeds, 17 Springfield Mount, Leeds, LS2 9NG, UK

    Eve Roman & Ray A. Cartwright

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  1. Richard J.Q. McNally
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  2. Eve Roman
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  3. Ray A. Cartwright
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McNally, R.J., Roman, E. & Cartwright, R.A. Leukemias and lymphomas: time trends in the UK, 1984–93. Cancer Causes Control 10, 35–42 (1999). https://doi.org/10.1023/A:1008859730818

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