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Anthropometric indices as predictors of survival in AIDS adults. Aquitaine Cohort, France, 1985–1997

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Abstract

The aim of the study was to assess the performance of weight related nutritional markers [reported involuntary weight loss (WL) greater than 10%, measured WL and body mass index (BMI)] in predicting survival at AIDS stage. The three anthropometric indices were used as time dependant variables in Cox models to predict survival at AIDS stage. The studied sample included 630 HIV1-infected individuals of a prospective cohort of those 421 died (median survival at AIDS stage: 19.9 months). After adjustment for usual prognostic factors of survival, the reported WL greater than 10% was a pejorative predictor of survival (hazard ratio (HR) 2.4; 95% confidence interval (CI): 1.9–3.0). For measured WL <5%, between 5 and 10% and ≥10% of baseline weight compared with no WL, HR were respectively, 1.9 (CI: 1.4–2.6), 3.3 (CI: 2.4–4.4) and 6.7 (CI: 5.2–8.6). The HR of death were 2.2 (CI: 1.6–3.0) for BMI between 16 and 18.4 kg/m2and 4.4 (CI: 3.1–6.3) for BMI <16 compared to normal BMI (≥18.5). Even a limited WL measured at a given point in time during follow up increases the risk of death at the AIDS stage. Simple cross-sectional measures of BMI have a good predictive value of survival.

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Authors and Affiliations

  1. Unité INSERM 330, Université Victor Segalen Bordeaux 2, Bordeaux, France

    Thiébaut Rodolphe, Malvy Denis, Marimoutou Catherine & Dabis François

  2. Service de Médecine Interne, Centre Hospitalier Universitaire (CHU) de Bordeaux, France

    Malvy Denis

  3. Centre d'Information et de Soins de l'Immunodéficience Humaine, CHU de Bordeaux, France

    Marimoutou Catherine

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  1. Thiébaut Rodolphe
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  2. Malvy Denis
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  3. Marimoutou Catherine
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  4. Dabis François
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Rodolphe, T., Denis, M., Catherine, M. et al. Anthropometric indices as predictors of survival in AIDS adults. Aquitaine Cohort, France, 1985–1997. Eur J Epidemiol 16, 633–639 (2000). https://doi.org/10.1023/A:1007696530440

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