Abstract
What was the first living molecule – RNA or protein?This question embodies the major disagreement instudies on the origin of life. The fact that incontemporary cells RNA polymerase is a protein andpeptidyl transferase consists of RNA suggests theexistence of a mutual catalytic dependence betweenthese two kinds of biopolymers. I suggest that thisdependence is a `frozen accident', a remnant from thefirst living system. This system is proposed to be acombination of an RNA molecule capable of catalyzingamino acid polymerization and the resulting proteinfunctioning as an RNA-dependent RNA polymerase. Thespecificity of the protein synthesis is thought to beachieved by the composition of the surrounding mediumand the specificity of the RNA synthesis – by Watson– Crick base pairing. Despite its apparent simplicity,the system possesses a great potential to evolve intoa primitive ribosome and further to life, as it isseen today. This model provides a possible explanationfor the origin of the interaction between nucleicacids and protein. Based on the suggested system, Ipropose a new definition of life as a system ofnucleic acid and protein polymerases with a constantsupply of monomers, energy and protection.
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Bar-Nun, A., Bar-Nun, N., Bauer S. H. and Sagan, C.: 1970, Science 168, 470.
Bloch, D. P., McArthur, B. and Mirrop, S.: 1985, Biosystems 17, 209.
Bloch, D. P., McArthur, B., Guimaraes, R. C., Smith, J. and Staves, M. P.: 1989, Braz. J. Med. Biol. Res. 22, 931.
Cech, T. R.: 1986, Proc. Natl. Acad. Sci. U.S.A. 83, 4360.
Dyson, F. J.: 1982, J. Mol. Evol. 18, 344.
Ekland, E. H., Szostak, J. W. and Bartel, D. P.: 1995, Science 269, 364.
Ekland, E. H. and Bartel, D. P.: 1996, Nature 382, 373.
Ferris, J. P. and Ertem, G.: 1992, Science 257, 1387
Ferris, J. P.: 1993, Origins Life Evol. Biosphere 23, 307.
Fox, S. W. and Windsor, C. R.: 1970, Science 170, 984.
Fox, S. W. and Dose, K.: 1977, Molecular Evolution and the Origin of Life, Dekker, New York.
Francklyn, C. and Schimmel, P.: 1990, Proc. Natl. Acad. Sci. U.S.A. 87, 8655.
Francklyn, C., Shi, J. P. and Schimmel, P.: 1992, Science 255, 1121.
Frugier, M., Florentz, C. and Giege, R.: 1994, EMBO J. 13, 2219.
Gesteland, R. F. and Atkins, J. F. (eds.): 1993, The RNA World, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1993.
Green, R. and Noller, H.: 1997, Ann. Rev. Biochem. 66, 191.
Hansen, J. L., Long, A. M. and Schultz, S. C.: 1997, Structure 5, 1109.
Harada, K. and Fox, S. W.: 1964, Nature 20, 335.
Hill Jr., A. R., Bohler, C. and Orgel, L. E.: 1998, Origins Life Evol. Biosphere 28, 235.
Joyce, G. F.: 1989, Nature 338, 217.
Kauffman, S.: 1986, J. Theor. Biol. 119, 1.
Lahav, N., White, D. and Chang, S.: 1978, Science 201, 67.
Lahav, N.: 1993, Origins Life Evol. Biosphere 23, 329.
Lahav, N. and Nir, S.: 1997, Origins Life Evol. Biosphere 27, 377.
Lawless, J. G. and Levi, N.: 1979, J. Mol. Evol. 13, 281.
Lazcano, A., Fastag, J., Gariglio, P., Ramirez, C. and Oro, J.: 1988, J. Mol. Evol. 27, 365.
Lee, D. H., Granja, J. R., Martinez, J. A., Severin, K. and Ghadri, M. R.: 1996, Nature 382, 525.
Maizels, N. and Weiner, A. M.: 1994, Proc. Natl. Acad. Sci. U.S.A. 91, 6729.
Miller, S. L. and Urey, H. C.: 1959, Science 130, 245.
Noller, H. F., Hoffarth, V. and Zimniak, L.: 1992, Science 256, 1416.
Odom, D. G., Lahav, N. and Chang, S.: 1979, J. Mol. Evol. 12, 259.
Ohnishi, K.: 1992, Nucleic Acids Symp. Ser. 27, 145.
Orgel, L. E.: 1998, Trends Biochem. Sci. 23, 491.
Rich, A.: 1962, in Horizons in Biochemistry, in Kasha, M. and Pullman (eds.), Academic Press, NY, pp. 103–126.
Saetia, S., Liedl, K. R., Eder, A. H. and Rode, B. M.: 1993, Origins Life Evol. Biosphere 23, 167.
Saks, M. E. and Sampson, J. R.: 1996, EMBO J. 15, 2843.
Sievers, D. and von Kiedrowski, O.: 1994, Nature 369, 221.
Staves, M. P., Bloch, D. P. and Lacey, J. C.: 1988, Z. Naturforsch. 43, 476.
Staves, M. P. and Lacey, J. C.: 1989, Z. Naturforsch. 44, 296.
Trifonov, E. N. and Bettecken, T.: 1997, Gene 205, 1.
Zhang, B. and Cech, T. R.: 1997, Nature 390, 96.
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Kunin, V. A System of Two Polymerases – A Model for the Origin of Life. Orig Life Evol Biosph 30, 459–466 (2000). https://doi.org/10.1023/A:1006672126867
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DOI: https://doi.org/10.1023/A:1006672126867