Neurotherapeutics

, Volume 6, Issue 2, pp 402–405

The ketogenic diet: Proposed mechanisms of action

Authors

  • Kirk Nylen
    • Department of Pharmacology and University of Toronto Epilepsy Research Program (UTERP)University of Toronto
  • Sergei Likhodii
    • Department of Pharmacology and University of Toronto Epilepsy Research Program (UTERP)University of Toronto
    • Department of Pharmacology and University of Toronto Epilepsy Research Program (UTERP)University of Toronto
    • Department of Pharmacology
Theme 5: Hormonal and Dietary Therapy

DOI: 10.1016/j.nurt.2009.01.021

Cite this article as:
Nylen, K., Likhodii, S. & Burnham, W.M. Neurotherapeutics (2009) 6: 402. doi:10.1016/j.nurt.2009.01.021

Summary

The ketogenic diet is a high-fat, low-carbohydrate diet used to treat drug-resistant seizures, especially in children. A number of possible mechanisms of action have been proposed to explain the anticonvulsant effects of the diet. Four of these hypothetical mechanisms are discussed in the present article: the pH hypothesis, the metabolic hypotheses, the amino acid hypothesis, and the ketone hypothesis.

Key Words

Epilepsy ketogenic diet pH hypothesis metabolic hypothesis amino acid hypothesis ketone hypothesis

Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2009