The ketogenic diet: Proposed mechanisms of action
- Cite this article as:
- Nylen, K., Likhodii, S. & Burnham, W.M. Neurotherapeutics (2009) 6: 402. doi:10.1016/j.nurt.2009.01.021
The ketogenic diet is a high-fat, low-carbohydrate diet used to treat drug-resistant seizures, especially in children. A number of possible mechanisms of action have been proposed to explain the anticonvulsant effects of the diet. Four of these hypothetical mechanisms are discussed in the present article: the pH hypothesis, the metabolic hypotheses, the amino acid hypothesis, and the ketone hypothesis.