Journal of Nuclear Cardiology

, Volume 14, Issue 4, pp 573–581

Sex differences in myocardial oxygen and glucose metabolism

  • Linda R. Peterson
  • Pablo F. Soto
  • Pilar Herrero
  • Kenneth B. Schechtman
  • Carmen Dence
  • Robert J. Gropler
Original Articles

DOI: 10.1016/j.nuclcard.2007.03.001

Cite this article as:
Peterson, L.R., Soto, P.F., Herrero, P. et al. J Nucl Cardiol (2007) 14: 573. doi:10.1016/j.nuclcard.2007.03.001

Abstract

Background

Both physiologic and pathophysiologic conditions affect the myocardium’s substrate use and, consequently, its structure, function, and adaptability. The effect of sex on myocardial oxygen, glucose, and fatty acid metabolism in humans is unknown.

Methods and Results

We studied 25 young subjects (13 women and 12 men) using positron emission tomography, quantifying myocardial blood flow, myocardial oxygen consumption (MVO2), and glucose and fatty acid extraction and metabolism. MVO2 was higher in women than in men (5.74±1.08 μmol·g−1·min−1 vs 4.26±0.69 μmol·g−1·min−1,P<.005). Myocardial glucose extraction fraction and utilization were lower in women than in men (0.025±0.019 vs 0.062±0.028 [P<.001] and 133±96 nmol·g−1·min−1 vs 287±164 nmol·g−1·min−1 [P<.01], respectively). There were no sex differences in myocardial blood flow, fatty acid metabolism, or plasma glucose, fatty acid, or insulin levels. Female sex was an independent predictor of increased MVO2 (P=.01) and decreased myocardial glucose extraction fraction and utilization (P<.005 andP<.05, respectively). Insulin sensitivity was an independent predictor of increased myocardial glucose extraction fraction and utilization (P<.01 andP=.01, respectively).

Conclusions

Further studies are necessary to elucidate the mechanisms responsible for sex-associated differences in myocardial metabolism. However, the presence of such differences may provide a partial explanation for the observed sex-related differences in the prevalence and manifestation of a variety of cardiac disorders.

Key Words

Sex myocardial metabolism glucose myocardial oxygen consumption 

Copyright information

© American Society of Nuclear Cardiology 2007

Authors and Affiliations

  • Linda R. Peterson
    • 1
    • 2
    • 3
  • Pablo F. Soto
    • 1
  • Pilar Herrero
    • 3
  • Kenneth B. Schechtman
    • 4
  • Carmen Dence
    • 3
  • Robert J. Gropler
    • 1
    • 3
  1. 1.Cardiovascular DivisionMallinckrodt Institute of RadiologySt Louis
  2. 2.Division of Geriatries and Nutritional Sciences, Department of MedicineMallinckrodt Institute of RadiologySt Louis
  3. 3.Department of Radiological SciencesMallinckrodt Institute of RadiologySt Louis
  4. 4.Division of BiostatisticsWashington University School of MedicineSt Louis

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