Journal of the American Society for Mass Spectrometry

, Volume 19, Issue 12, pp 1821–1831

A linear ion trap mass spectrometer with versatile control and data acquisition for ion/ion reactions


  • Matthew W. Soyk
    • Department of ChemistryIowa State University
  • Qin Zhao
    • Department of ChemistryIowa State University
  • R. S. Houk
    • Department of ChemistryIowa State University
    • Ames Laboratory, U.S. Department of EnergyIowa State University
    • Nonclinical SafetyHoffman-La Roche Inc.

DOI: 10.1016/j.jasms.2008.08.020

Cite this article as:
Soyk, M.W., Zhao, Q., Houk, R.S. et al. J Am Soc Mass Spectrom (2008) 19: 1821. doi:10.1016/j.jasms.2008.08.020


A linear ion trap (LIT) with electrospray ionization (ESI) for top-down protein analysis has been constructed. An independent atmospheric sampling glow discharge ionization (ASGDI) source produces reagent ions for ion/ion reactions. The device is also meant to enable a wide variety of ion/ion reaction studies. To reduce the instrument’s complexity and make it available for wide dissemination, only a few simple electronics components were custom built. The instrument functions as both a reaction vessel for gas-phase ion/ion reactions and a mass spectrometer using mass-selective axial ejection. Initial results demonstrate trapping efficiency of 70% to 90% and the ability to perform proton transfer reactions on intact protein ions, including dual polarity storage reactions, transmission mode reactions, and ion parking.

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© American Society for Mass Spectrometry 2008