Journal of the American Society for Mass Spectrometry

, Volume 18, Issue 8, pp 1559–1567

Suppression and enhancement of secondary ion formation due to the chemical environment in static-secondary ion mass spectrometry

Authors

    • Surface Analysis Research Centre, Manchester Interdisciplinary Biocentre, CEASUniversity of Manchester
  • Nicholas P. Lockyer
    • Surface Analysis Research Centre, Manchester Interdisciplinary Biocentre, CEASUniversity of Manchester
  • Jeanette Kordys
    • Surface Analysis Research Centre, Manchester Interdisciplinary Biocentre, CEASUniversity of Manchester
  • John C. Vickerman
    • Surface Analysis Research Centre, Manchester Interdisciplinary Biocentre, CEASUniversity of Manchester
Articles

DOI: 10.1016/j.jasms.2007.05.014

Cite this article as:
Jones, E.A., Lockyer, N.P., Kordys, J. et al. J Am Soc Mass Spectrom (2007) 18: 1559. doi:10.1016/j.jasms.2007.05.014

Abstract

Through analyzing mixtures of compounds of known gas-phase basicities, the importance of this property on the secondary ions emitted from a surface under primary ion bombardment is investigated. The aim is to obtain a greater understanding of the ionization mechanisms that occur in secondary ion mass spectrometry (SIMS). The commonly used matrix assisted laser desorption/ionization (MALDI) matrix 2,4,6-trihydroxyacetophenone (THAP) and a range of low molecular weight biomolecules were used to investigate whether analyte/matrix suppression effects that have been observed in analogous MALDI experiments were also present in static-SIMS. The outcome of the experiments demonstrates that strong suppression of the quasi-molecular signal of one molecule in a mixture can occur due to the presence of the other, with the gas-phase basicity of the compounds being a good indicator of the secondary ions detected. It is also demonstrated that the suppression of the quasi-molecular ion signal of a compound in a two-component mixture can be minimized by the inclusion of a third compound of suitable gas-phase basicity.

Copyright information

© American Society for Mass Spectrometry 2007