A study of noncovalent protein complexes by matrix-assisted laser desorption/ionization

Short Communication

DOI: 10.1016/j.jasms.2007.03.026

Cite this article as:
Song, F. J Am Soc Mass Spectrom (2007) 18: 1286. doi:10.1016/j.jasms.2007.03.026


A sample preparation method has been developed for detection of noncovalent protein—protein complexes by MALDI in this work. An aqueous solution of the matrix at pH 7 allows the reproducible detection of a protein dimer, a protein tetramer, and a heterodimer. The signals are stable under long irradiation and can be detected at wide ranges of concentrations and with different laser intensities.

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© American Society for Mass Spectrometry 2007

Authors and Affiliations

  1. 1.Center for Advanced Research in BiotechnologyUniversity of Maryland Biotechnology InstituteRockvilleUSA
  2. 2.U.S. Food and Drug AdministrationCenter for Food Safety and Applied NutritionCollege ParkUSA

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