Investigation of noncovalent complexes between β-cyclodextrin and polyamide acids containing N-methylpyrrole and N-methylimidazole by electrospray ionization mass spectrometry
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- Li, H., Zhou, J., Tang, F. et al. J Am Soc Mass Spectrom (2006) 17: 9. doi:10.1016/j.jasms.2005.08.011
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Electrospray ionization (ESI) mass spectrometry was utilized to investigate noncovalent complexes between β-cyclodextrin (β-CD) and five novel polyamide acids containing N-methylpyrrole and N-methylimidazole. The 1:1 binding mode was specified by examining the binding stoichiometry from ESI mass spectra. It found that polyamide acids with β-CD have binding affinities in the order: ImImImβCOOH > ImPyImβCOOH > ImPyPyβCOOH > PyPyPyβCOOH > NO2PyPyPyβCOOH. The method gives, simultaneously, the binding constants between β-CD and polyamide acids based on a novel linear equation.