Investigation of noncovalent complexes between β-cyclodextrin and polyamide acids containing N-methylpyrrole and N-methylimidazole by electrospray ionization mass spectrometry

Articles

DOI: 10.1016/j.jasms.2005.08.011

Cite this article as:
Li, H., Zhou, J., Tang, F. et al. J Am Soc Mass Spectrom (2006) 17: 9. doi:10.1016/j.jasms.2005.08.011

Abstract

Electrospray ionization (ESI) mass spectrometry was utilized to investigate noncovalent complexes between β-cyclodextrin (β-CD) and five novel polyamide acids containing N-methylpyrrole and N-methylimidazole. The 1:1 binding mode was specified by examining the binding stoichiometry from ESI mass spectra. It found that polyamide acids with β-CD have binding affinities in the order: ImImImβCOOH > ImPyImβCOOH > ImPyPyβCOOH > PyPyPyβCOOH > NO2PyPyPyβCOOH. The method gives, simultaneously, the binding constants between β-CD and polyamide acids based on a novel linear equation.

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© American Society for Mass Spectrometry 2005

Authors and Affiliations

  1. 1.Department of Chemical Biology, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of ChemistryPeking UniversityBeijingChina

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