Bulletin of Mathematical Biology

, Volume 67, Issue 1, pp 79–99

A mathematical model of Doxorubicin treatment efficacy for non-Hodgkin’s lymphoma: Investigation of the current protocol through theoretical modelling results

  • B. Ribba
  • K. Marron
  • Z. Agur
  • T. Alarcón
  • P. K. Maini
Article

DOI: 10.1016/j.bulm.2004.06.007

Cite this article as:
Ribba, B., Marron, K., Agur, Z. et al. Bull. Math. Biol. (2005) 67: 79. doi:10.1016/j.bulm.2004.06.007

Abstract

Doxorubicin treatment outcomes for non-Hodgkin’s lymphomas (NHL) are mathematically modelled and computationally analyzed. The NHL model includes a tumor structure incorporating mature and immature vessels, vascular structural adaptation and NHL cell-cycle kinetics in addition to Doxorubicin pharmacokinetics (PK) and pharmacodynamics (PD). Simulations provide qualitative estimations of the effect of Doxorubicin on high-grade (HG), intermediate-grade (IG) and low-grade (LG) NHL. Simulation results imply that if the interval between successive drug applications is prolonged beyond a certain point, treatment will be inefficient due to effects caused by heterogeneous blood flow in the system.

Copyright information

© Society for Mathematical Biology 2005

Authors and Affiliations

  • B. Ribba
    • 1
    • 3
  • K. Marron
    • 1
  • Z. Agur
    • 1
  • T. Alarcón
    • 2
    • 4
  • P. K. Maini
    • 2
  1. 1.Institute for Medical BioMathematicsBene AtarothIsrael
  2. 2.Centre for Mathematical Biology, Mathematical InstituteUniversity of OxfordOxfordUK
  3. 3.Clinical Pharmacology Unit, Faculty of Medicine LaënnecUniversity of LyonLyonFrance
  4. 4.Bioinformatics Unit, Department of Computer ScienceUniversity College LondonLondonUK