Skip to main content
SpringerLink
Log in

Primary cystic neoplasms of the pancreas: neoplastic disorders of emerging importance—current state-of-the-art and unanswered questions

  • State-of-the-Art Review
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Compagno J, Oertel JE. Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma). A clinicopathologic study of 41 cases. Am J Clin Pathol 1978;69:573–580.

    PubMed  CAS  Google Scholar 

  2. Compagno J, Oertel JE. Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): A clinicopathologic study of 34 cases. Am J Clin Pathol 1978;69:289–298.

    PubMed  CAS  Google Scholar 

  3. Ohashi K, Murakami Y, Takekoshi T, Ohta H, Ohashi I. Four cases of ucin producing cancer of the pancreas on specific findings of the papilla of Vater. Prog Dig Endosc 1982; 20:348–351.

    Google Scholar 

  4. Libsch, K, Tollefson M, Duininck TM, Zyromski N, Chari S, Sarr MG, Smyrk TC. Intraductal papillary mucinous tumor (IPMT) of the pancreas. Did it exist before 1980?[abstr] Pancreas 2001;23:449.

    Google Scholar 

  5. Thompson LDR, Becker RC, Przygodzki RM, Adair CF, Heffess CS. Mucinous cystic neoplasm (mucinous cystade-nocarcinoma of low grade malignant potential) of the pancreas. Am J Surg Pathol 1999;23:1–16.

    Article  PubMed  CAS  Google Scholar 

  6. Sarr MG, Carpenter HA, Prabhakar LP, Orchard TF, Hughes S, van Heerden JA, DiMagno EP. Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas —can one reliably differentiate benign from malignant (or premalignant neoplasms? Ann Surg 2000; 231:205–212.

    Article  PubMed  CAS  Google Scholar 

  7. Talamini MA, Pitt HA, Hruban RH, Boitnott JK, Coleman JA Cameron JL. Spectrum of cystic tumors of the pancreas. Am J Surg 1992;163:117–124.

    Article  PubMed  CAS  Google Scholar 

  8. Warshaw AL, Compton CC, Lewandrowski K, Cardenosa G, Muller PR. Cystic tumors of the pancreas: New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg 1990;212:432–445.

    Article  PubMed  CAS  Google Scholar 

  9. George DH, Murphy F, Michalski R, Ulmer BG. Serous cystadenocarcinoma of the pancreas—A new entity? Am J Surg Pathol 1989;13:61–66.

    Article  PubMed  CAS  Google Scholar 

  10. Zamboni G, Scarpa A, Bogina G, Iacona C, Bassi C, Talamini G, Sessa F, Capella C, Solcia E, Rickaert F, Mariuzzi GM, Kloppel G. Mucinous cystic tumors of the pancreas. Am J Surg Pathol 1999;23:410–422.

    Article  PubMed  CAS  Google Scholar 

  11. Chari ST, Raimondo M, Clain JE, Norton ID, Pearson RK, Petersen BT, Miller LJ, Farnell M, Sarr MG, DiMagno EP. Is benign pancreatic intraductal papillary tumor (IPMT) truly benign? Gastroenterology 2000;18(Suppl 1):A642.

    Article  Google Scholar 

  12. Iacobuzi-Donahue CA, Klimstra DS, Adsay NV, Wilentz RE, Arganai P, Sohn TA, Yeo CJ, Cameron JL, Kern SE, Hruban H. DPC-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas. Am J Surg Pathol 2000;157:755–761.

    Google Scholar 

  13. Itai Y, Ohashi K, Nagai H, Murakami Y, Kokubo T, Makita K, Ohtomo K. “Ductectatic” mucinous cystadenoma and cystadenocarcinoma of the pancreas. Radiology 1986;161:697–700.

    PubMed  CAS  Google Scholar 

  14. Kobari M, Egawa S, Shibuya K, Shimamura H, Sanamura M, Takeda K, Matsuno S, Furukawa T. Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes. Arch Surg 1999;134:1131–1136.

    Article  PubMed  CAS  Google Scholar 

  15. Terris B, Ponsot P, Paye F, Hammel P, Sauvanet A, Molas G, Bernades P, Belghiti J, Ruszniewski P, Flejou JF. Intraductal papillary mucinous tumors of the pancreas confined to secondary ducts show less aggressive pathologic features as compared with those involving the main pancreatic duct. Am J Surg Pathol 2000;24:1372–1377.

    Article  PubMed  CAS  Google Scholar 

  16. Adsay NV, Longnecker DS, Klimstra DS. Pancreatic tumors with cystic dilatation of the ducts: Intraductal papillary mucinous neoplasms and intraductal oncocytic papillary neoplasms. Semin Diag Pathol 2000;17:16–30.

    CAS  Google Scholar 

  17. Andea AA, Cheng J, Lauwers GY, Klimstra DS. Assay in pancreatic intraepithelial neoplasia (Panin) in pacreata involved by mucinous cystic neoplasm. Mod Pathol 2002;15:282A.

    Google Scholar 

  18. Adsay NV, Conlon KC, Zee SY, Brennan MF, Klimstra DS. Intraductal papillary mucinous neoplasms of the pancreas. An analysis of in situ and invasive carcinomas in 28 patients. Cancer 2002;94:62–77.

    Article  PubMed  Google Scholar 

  19. Wilentz RE, Saavedra JA, Hruban RH. Mucinous cystic neoplasms of the pancreas. Semin Diag Pathol 2000;17:31–42.

    CAS  Google Scholar 

  20. Johnson CD, Stephens DH, Charboneau JW, Carpenter HA, Welch TS. Cystic pancreatic tumors: CT and sonographic assessment. Am J Roentgenol 1988;151:1133–1138.

    CAS  Google Scholar 

  21. Warshaw AL, Compton CC, Lewandrowski K, Cardenosa G, Mueller PR. Cystic tumors of the pancreas: New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg 1990;212:432–445.

    Article  PubMed  CAS  Google Scholar 

  22. Fukukura Y, Fujiyoshi F, Sasaki M, Inoue H, Yonezawa S, Nakajo M. Intraductal papillary mucinous tumors of the pancreas: Thin-section helical CT findings. Am J Roentgenol 2000;174:441–447.

    CAS  Google Scholar 

  23. Taouli B, Vilrain V, Vullierme M-P, Terris B, Denys A, Sqvanet A, Hammell P, Menu Y. Intraductal papillary mucinous tumors of the pancreas: Helical CT with histopathologic correlation. Radiology 2000;217:757–764.

    PubMed  CAS  Google Scholar 

  24. Procacci C, Megibow AJ, Carbognin G, Guarise A, Spoto E, Biasiutti C, Pistolesi GF. Intraductal papillary mucinous tumor of the pancreas: a pictorial essay. Radiographics 1999; 19:1447–1463.

    PubMed  CAS  Google Scholar 

  25. Seo DW, Kim MH, Lee SK, Yoo BM, Jung SA, Myung SJ, Min YI, Gong G, Auh YH. The value of pancreatoscopy in patients with mucinous ductal ectasia. Endoscopy 1997;29:315–318.

    Article  PubMed  CAS  Google Scholar 

  26. Yamao K, Ohashi K Nakamura T, Suzuki T, Watanabe Y, Shimizu Y, Nakamura Y, Ozden I. Evaluation of various imaging methods in the differential diagnosis of intraductal papillary mucinous tumor (IPMT) of the pancreas. Hepatogastroenterology 2001;48:962–966.

    PubMed  CAS  Google Scholar 

  27. Hara T, Yamaguchi T, Ishihara T, Tsuyuchi T, Kondo F, Kato K, Asano T, Saisho H. Diagnosis and patient management of intraductal papillary mucinous tumor of the pancreas by using peroral pancreatoscopy and intraductal ultrasonography. Gastroenterology 2002;122:34–43.

    Article  PubMed  Google Scholar 

  28. Traverso LW, Peralta EA, Ryan JA Jr, Kozarek RA. Intraductal neoplasms of the pancreas. Am J Surg 1998;175:426–432.

    Article  PubMed  CAS  Google Scholar 

  29. Yamaguchi K, Ogawa Y, Chijiiwa K, Tanaka M. Mucinhypersecreting tumors of the pancreas: assessing grade of malignancy preoperatively. Am J Surg 1996;171:427–431.

    Article  PubMed  CAS  Google Scholar 

  30. Lewandrowski KB, Southern JF, Pins MR, Compton CC, Warshaw AL. Cyst fluid analysis in the differential diagnosis of pancreatic cysts: A comparison of pseudocysts, serous cystadenomas, mucinous cystic neoplasms, and mucinous cystadenocarcinoma. Ann Surg 1993;217:41–47.

    Article  PubMed  CAS  Google Scholar 

  31. Hammel P, Levy P, Voitot H, Levy M, Vilgrain V, Zins M, Flejou JF, Molas G, Ruszniewski P, Bernades P. Preoperative cyst fluid analysis is useful for the differential diagnosis of cystic lesions of the pancreas. Gastroenterology 1995; 108:1230–1235.

    Article  PubMed  CAS  Google Scholar 

  32. Vehara H, Nakaizumi A, Iishi H, Tatsuta M, Kitamra T, Okuda S, Ohigashi H, Ishikawa O, Takenana A, Ishiguro S. Cytologic examination of pancreatic juice for differential diagnosis of benign and malignant mucin-producing tumors of the pancreas. Cancer 1994;74:826–833.

    Article  Google Scholar 

  33. Sperti C, Pasquali C, Guolo P, Polverosi R, Liessi G, Pedrazzoli S. Serum tumor markers and cyst fluid analysis are useful for the diagnosis of pancreatic cystic tumors. Cancer 1996;78:237–243.

    Article  PubMed  CAS  Google Scholar 

  34. Sperti C, Pasquali C, Chierichetti F, Liessi G, Ferlin G, Pedrazzoli S. Value of 18-fluorodeoxyglucose positron emission tomography in the management of patients with cystic tumors of the pancreas. Ann Surg 2001;234:675–680.

    Article  PubMed  CAS  Google Scholar 

  35. Pike CM, van Heerden JA, Colby TV, Sarr MG, Weaver AL: The spectrum of serous cystadenoma of the pancreas: Clinical, pathological, and surgical aspects. Ann Surg 1992; 215:132–139.

    Article  Google Scholar 

  36. Megibow AJ, Lombardo FP, Guarise A, Carbognin G, Scholes J, Rofsky NM, Macari M, Balthazar EJ, Procacci C. Cystic pancreatic masses: Cross-sectional imaging observations and serial follow-up. Abdom Imaging 2001;26:640–647.

    Article  PubMed  CAS  Google Scholar 

  37. Talamini MA, Moesinger R, Yeo CJ, Poulouse B, Hruban RH, Cameron JL, Pitt HA. Cystadenomas of the pancreas: Is enucleation an adequate operation? Ann Surg 1998;227:896–903.

    Article  PubMed  CAS  Google Scholar 

  38. Jiminez RE, Warshaw AL, Z’graggen K, Hartwig W, Taylor DZ, Compton CC, Fernandez-del-Castillo C. Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy. Ann Surg 1999;230:501–511.

    Article  Google Scholar 

  39. Delcore R, Thomas JH, Forster J, Hermreck AS. Characteristics of cystic neoplasms of the pancreas and results of aggressive surgical treatment. Am J Surg 1992;164:437–442.

    Article  PubMed  CAS  Google Scholar 

  40. Hodgkinson DJ, ReMine WH, Weiland LH. A clinicopathologic study of 21 cases of pancreatic cystadenocarcinoma. Ann Surg 1978;188:679–684.

    Article  PubMed  CAS  Google Scholar 

  41. Wilentz RE, Albores-Saavedra J, Zahurak M, Talamini MA, Yeo CJ, Cameron JL, Hruban RH. Pathologic examination accurately predicts prognosis in mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 1999;23:1320–1327.

    Article  PubMed  CAS  Google Scholar 

  42. Wood D, Silberman AW, Heifetz L, Memsic L, Shabot MM. Cystadenocarcinoma of the pancreas: Neo-adjuvant therapy and CEA monitoring. J Surg Oncol 1990;43:56–60.

    Article  PubMed  CAS  Google Scholar 

  43. Sohn TA, Yeo CJ, Cameron JL, Iacobozio-Donahue CA, Hruban RH, Lillemoe KD. Intraductal papillary mucinous neoplasms of the pancreas: An increasingly recognized clinicopathological entity. Ann Surg 2001;234:313–322.

    Article  PubMed  CAS  Google Scholar 

  44. Paye F, Sauvanet A, Terris B, Ponsot P, Vilgrain V, Hammel P, Bernades P, Ruszniewski P, Belghiti J. Intraductal papillary mucinous tumors of the pancreas: Pancreatic resections guided by preoperative morphological assessment and intraoperative frozen section examination. Surgery 2000; 127:536–544.

    Article  PubMed  CAS  Google Scholar 

  45. Cuillerier E, Cellier C, Palazzo L, Deviere J, Wind P, Rickaert F, Cugenc PA, Cremer M, Barbier JP. Outcome after surgical resection of intraductal papillary and mucinous tumors of the pancreas. Am J Gastroenterol 2000;95:441–445.

    Article  PubMed  CAS  Google Scholar 

  46. Falconi M, Salvia R, Bassi C, Zamboni G, Talamini G, Pederzoli P. Clinicopathological features and treatment of intraductal papillary mucinous tumors of the pancreas. Br J Surg 2001;88:376–381.

    Article  PubMed  CAS  Google Scholar 

  47. Traverso WL, Peralta EA, Ryan JA, Kozarek RA. Intraductal neoplasms of the pancreas. Am J Surg 1998;175:426–432.

    Article  PubMed  CAS  Google Scholar 

  48. Longnecker DS, Adler G, Hruban R, Kloppel G. Intraductal papillary mucinous neoplasms of the pancreas. In Hamilton SR, Aaltonen LA, eds. World Health Organization Classification of tumours. Tumours of the digestive system. Washington, DC: IARC Press, 2000, pp 237–240.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Mayo Clinic, 200 First Street SW (AL 2-435), 55905, Rochester, MN

    Michael G. Sarr M.D. (Professor of Surgery)

  2. Department of Pathology, Mayo Clinic, Rochester, Minnesota

    Thomas C. Smyrk M.D.

  3. Department of Surgery, University of South Florida, Tampa, Florida

    Michel Murr M.D.

  4. Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland

    Charles J. Yeo M.D.

  5. Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts

    Carlos Fernandez-del-Castillo M.D.

  6. Department of Gastroenterology, Medical University of South Carolina, Charleston, South Carolina

    Robert H. Hawes M.D.

  7. Department of Radiology, University of Washington, Seattle, Washington

    Patrick C. Freeny M.D.

Authors
  1. Michael G. Sarr M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michel Murr M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Thomas C. Smyrk M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Charles J. Yeo M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Carlos Fernandez-del-Castillo M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Robert H. Hawes M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Patrick C. Freeny M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sarr, M.G., Murr, M., Smyrk, T.C. et al. Primary cystic neoplasms of the pancreas: neoplastic disorders of emerging importance—current state-of-the-art and unanswered questions. J Gastrointest Surg 7, 417–428 (2003). https://doi.org/10.1016/S1091-255X(02)00163-4

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1016/S1091-255X(02)00163-4

Keywords

Search

Navigation