Endgroup determination of synthetic polymers by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry

  • Sander Koster
  • Marc C. Duursma
  • Jaap J. Boon
  • Ron M. A. Heeren
Article

DOI: 10.1016/S1044-0305(00)00115-X

Cite this article as:
Koster, S., Duursma, M.C., Boon, J.J. et al. J Am Soc Mass Spectrom (2000) 11: 536. doi:10.1016/S1044-0305(00)00115-X

Abstract

Electrospray ionization (ESI) was performed on a Fourier transform ion cyclotron resonance mass spectrometer for the endgroup and monomer mass determination of three poly(oxyalkylene)s in the mass range of 400–8000 Da. A combined use of the multiple charge states observed with ESI, leads to a threefold increase in accuracy of the endgroup and monomer determination. The improvement is attributed to the increased number of datapoints used for the regression procedure, yielding more accurate results. Endgroup masses are determined with a mass error better than 5 and 75 millimass units for the molecular weight range of 400–4200 and 6200–8000 Da, respectively. A mass error of better than 1 millimass unit was observed for all monomer mass determinations. With ESI, endgroup and monomer masses have been determined for poly(ethylene glycol) oligomers with a mass higher than 8000 Da. This is almost two times higher than observed with matrix-assisted laser desorption/ ionization on the same instrument.

Copyright information

© American Society for Mass Spectrometry 2000

Authors and Affiliations

  • Sander Koster
    • 1
  • Marc C. Duursma
    • 1
  • Jaap J. Boon
    • 1
  • Ron M. A. Heeren
    • 1
  1. 1.Unit for Macromolecular Mass SpectrometryFOM-Institute for Atomic and Molecular PhysicsAmsterdamThe Netherlands