Skip to main content

Advertisement

SpringerLink
Log in

Co-morbid OSA and Depression: What We Know and What We Need to Know

  • Review
  • Published:
Sleep and Vigilance Aims and scope Submit manuscript

Abstract

Obesity is a common medical condition complicating psychiatric illnesses. Obstructive sleep apnea is a closely related disorder to obesity with hazardous consequences in terms of both morbidity and mortality. In this article, we have made a qualitative search of both primary studies and systematic reviews pertaining to co-morbid depression and OSA. Under a structured format, the article discusses the epidemiology, pathophysiology, therapeutic significance of the association followed by a conclusion for clinical, as well as research approaches to co-morbidity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. J Clin Sleep Med. 2012;8(5):597–619.

    PubMed  PubMed Central  Google Scholar 

  2. Andrade L, Caraveo-Anduaga JJ, Berglund P, Bijl RV, De Graaf R, Vollebergh W, et al. The epidemiology of major depressive episodes: results from the International Consortium of Psychiatric Epidemiology (ICPE) Surveys. Int J Methods Psychiatr Res. 2003;12(1):3–21.

    Article  PubMed  Google Scholar 

  3. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328(17):1230–5.

    Article  CAS  PubMed  Google Scholar 

  4. Udwadia ZF, Doshi AV, Lonkar SG, Singh CI. Prevalence of sleep-disordered breathing and sleep apnea in middle-aged urban Indian men. Am J Respir Crit Care Med. 2004;169(2):168–73.

    Article  PubMed  Google Scholar 

  5. Bixler EO, Vgontzas AN, Ten Have T, Tyson K, Kales A. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med. 1998;157(1):144–8.

    Article  CAS  PubMed  Google Scholar 

  6. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177(9):1006–14.

    Article  PubMed  PubMed Central  Google Scholar 

  7. McCall WV, Harding D, O’Donovan C. Correlates of depressive symptoms in patients with obstructive sleep apnea. J Clin Sleep Med. 2006;2(4):424–6.

    PubMed  Google Scholar 

  8. Pinto JA, Ribeiro DK, Cavallini AF, Duarte C, Freitas GS. Comorbidities associated with obstructive sleep apnea: a retrospective study. Int Arch Otorhinolaryngol. 2016;20(2):145–50.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Stubbs B, Vancampfort D, Veronese N, Solmi M, Gaughran F, Manu P, et al. The prevalence and predictors of obstructive sleep apnea in major depressive disorder, bipolar disorder and schizophrenia: a systematic review and meta-analysis. J Affect Disord. 2016;197:259–67.

    Article  PubMed  Google Scholar 

  10. Carney RM, Howells WB, Freedland KE, Duntley SP, Stein PK, Rich MW, et al. Depression and obstructive sleep apnea in patients with coronary heart disease. Psychosom Med. 2006;68(3):443–8.

    Article  PubMed  Google Scholar 

  11. Ong JC, Gress JL, San Pedro-Salcedo MG, Manber R. Frequency and predictors of obstructive sleep apnea among individuals with major depressive disorder and insomnia. J Psychosom Res. 2009;67(2):135–41.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Kelly T, Douglas L, Denmark L, Brasuell G, Lieberman DZ. The high prevalence of obstructive sleep apnea among patients with bipolar disorders. J Affect Disord. 2013;151(1):54–8.

    Article  PubMed  Google Scholar 

  13. Beebe DW, Gozal D. Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J Sleep Res. 2002;11(1):1–16.

    Article  PubMed  Google Scholar 

  14. Thomas RJ, Rosen BR, Stern CE, Weiss JW, Kwong KK. Functional imaging of working memory in obstructive sleep-disordered breathing. J Appl Physiol. 2005;98(6):2226–34.

    Article  PubMed  Google Scholar 

  15. Drevets WC. Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression. Prog Brain Res. 2000;126:413–31.

    Article  CAS  PubMed  Google Scholar 

  16. Videbech P. PET measurements of brain glucose metabolism and blood flow in major depressive disorder: a critical review. Acta Psychiatr Scand. 2000;101(1):11–20.

    Article  CAS  PubMed  Google Scholar 

  17. Deldin PJ, Phillips LK, Thomas RJ. A preliminary study of sleep-disordered breathing in major depressive disorder. Sleep Med. 2006;7(2):131–9.

    Article  PubMed  Google Scholar 

  18. World Health Organization. The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. 1st ed. Geneva: World Health Organization; 1992.

    Google Scholar 

  19. Miller GE, Stetler CA, Carney RM, Freedland KE, Banks WA. Clinical depression and inflammatory risk markers for coronary heart disease. Am J Cardiol. 2002;90(12):1279–83.

    Article  PubMed  Google Scholar 

  20. Lanquillon S, Krieg JC, Bening-Abu-Shach U, Vedder H. Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology. 2000;22(4):370–9.

    Article  CAS  PubMed  Google Scholar 

  21. Singh G, Jackson CA, Dobson A, Mishra GD. Bidirectional association between weight change and depression in mid-aged women: a population-based longitudinal study. Int J Obes. 2014;38(4):591–6.

    Article  CAS  Google Scholar 

  22. De Wit L, Luppino F, van Straten A, Penninx B, Zitman F, Cuijpers P. Depression and obesity: a meta-analysis of community-based studies. Psychiatry Res. 2010;178(2):230–5.

    Article  PubMed  Google Scholar 

  23. McMahon JP, Foresman BH, Chisholm RC. The influence of CPAP on the neurobehavioral performance of patients with obstructive sleep apnea hypopnea syndrome: a systematic review. WMJ. 2003;102(1):36–43.

    PubMed  Google Scholar 

  24. Yu BH, Ancoli-Israel S, Dimsdale JE. Effect of CPAP treatment on mood states in patients with sleep apnea. J Psychiatr Res. 1999;33(5):427–32.

    Article  CAS  PubMed  Google Scholar 

  25. Henke KG, Grady JJ, Kuna ST. Effect of nasal continuous positive airway pressure on neuropsychological function in sleep apnea–hypopnea syndrome. A randomized, placebo-controlled trial. Am J Respir Crit Care Med. 2001;163(4):911–7.

    Article  CAS  PubMed  Google Scholar 

  26. Borak J, Cieślicki JK, Koziej M, Matuszewski A, Zieliński J. Effects of CPAP treatment on psychological status in patients with severe obstructive sleep apnoea. J Sleep Res. 1996;5(2):123–7.

    Article  CAS  PubMed  Google Scholar 

  27. Muñoz A, Mayoralas LR, Barbé F, Pericás J, Agusti AG. Long-term effects of CPAP on daytime functioning in patients with sleep apnoea syndrome. Eur Respir J. 2000;15(4):676–81.

    Article  PubMed  Google Scholar 

  28. Fitgerald CT, Hiett E, Buysee DJ, Altıntaş N, Aikman G, Fırat H. Sleep apnea in a sample of patients with treatment resistant depression referred for electroconvulsive therapy. J Turk Sleep Med. 2015;2(1):7–10.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurology and Sleep Centre, L 23 Hauz Khas Enclave, New Delhi, 110016, India

    Manvir Bhatia & Saurav Khatiwada

Authors
  1. Manvir Bhatia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Saurav Khatiwada
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Manvir Bhatia.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bhatia, M., Khatiwada, S. Co-morbid OSA and Depression: What We Know and What We Need to Know. Sleep Vigilance 1, 7–11 (2017). https://doi.org/10.1007/s41782-017-0009-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s41782-017-0009-6

Keywords

Search

Navigation